2-Amino-6-methylpyrazine

CAS No.：5521-56-2

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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2-Amino-6-methylpyrazine Basic information

Product Name:	2-Amino-6-methylpyrazine
Synonyms:	2-AMINO-6-METHYLPYRAZINE;2-Amino-6-methylpyrazine 97%;2-AMINE-6-METHYLPYRAZINE;6-METHYLPYRAZIN-2-AMINE;6-METHYLPYRAZIN-2-YLAMINE;6-Methyl-2-pyrazinamine;6-Methylpyrazin-2-amine, 2-Amino-6-methyl-1,4-diazine;2-Amino-6-methylpyrazine97%
CAS:	5521-56-2
MF:	C5H7N3
MW:	109.13
EINECS:	691-008-9
Product Categories:	Piperazine series;Amines;Pyrazines, Pyrimidines & Pyridazines;Imidazoles & Benzimidazoles;Imidazoles & Benzimidazoles;Pyrazines, Pyrimidines & Pyridazines
Mol File:	5521-56-2.mol

2-Amino-6-methylpyrazine Chemical Properties

Melting point	122.0 to 126.0 °C
Boiling point	246.0±35.0 °C(Predicted)
density	1.155±0.06 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
form	Solid
pka	3.52±0.10(Predicted)
color	White to Yellow to Orange
CAS DataBase Reference	5521-56-2

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	22
Hazard Note	Irritant
HS Code	2933998090

MSDS Information

2-Amino-6-methylpyrazine Usage And Synthesis

Uses	6-Methylpyrazin-2-amine is used in the preparation of heterocyclic amides containing pyridyl sulfones as TYK-2 signaling inhibitors useful in treatment of inflammatory and autoimmune diseases.

2-Amino-6-methylpyrazine Preparation Products And Raw materials

Raw materials

Dimethyl 2-(6-chloropyrazin-2-yl)malonate hydrochloride-->2-Chloro-6-methylpyrazine-->Pyrazinecarboxylic acid, 3-amino-5-methyl- (7CI,8CI,9CI)-->METHYLZINC CHLORIDE-->2-AMINO-3,5-DIBROMO-6-METHYLPYRAZINE-->(6-CHLOROPYRAZIN-2-YL)ACETIC ACID-->2-HYDROXY-6-METHYLPYRAZINE-->7-methyllumizine-->2-Chloro-6-aminopyrazine-->Methylmagnesium Bromide-->DIMETHYLZINC

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