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| 2,4,6-Tri-tert-butylphenol Basic information |
| Product Name: | 2,4,6-Tri-tert-butylphenol | | Synonyms: | 2,4,6-TRI-TERT-BUTYLPHENOL;2,4,6-tris(1,1-dimethylethyl)-phenol;Tributylphenol,96%;2,4,6-Tri-tert-bulylphenol;Antioxidant 246;2,4,6-TRI-TERTIARY BUTYL PHENOL ( TTBP );2,4,6-Tri-tert-butylphenol,97%;2,4,6-Tri-tert-butylphenol ,98% | | CAS: | 732-26-3 | | MF: | C18H30O | | MW: | 262.43 | | EINECS: | 211-989-5 | | Product Categories: | Organics;Organic Building Blocks;Oxygen Compounds;Phenols;Building Blocks;C9 to C20+;Industrial/Fine Chemicals;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds | | Mol File: | 732-26-3.mol |
| 2,4,6-Tri-tert-butylphenol Chemical Properties |
| Melting point | 125-130 °C (lit.) | | Boiling point | 277 °C (lit.) | | density | 0.8640 | | vapor pressure | 0.073Pa at 25℃ | | refractive index | 1.5029 (estimate) | | Fp | 130 °C | | storage temp. | -70°C | | solubility | Chloroform (Slightly), DMSO (Slightly, Sonicated) | | pKa | 12.61±0.40(Predicted) | | form | buffered aqueous glycerol solution | | color | Off-White to Pale Yellow | | Water Solubility | insoluble | | BRN | 1913256 | | InChIKey | PFEFOYRSMXVNEL-UHFFFAOYSA-N | | LogP | 7.1 at 35℃ | | CAS DataBase Reference | 732-26-3(CAS DataBase Reference) | | NIST Chemistry Reference | Phenol, 2,4,6-tris(1,1-dimethylethyl)-(732-26-3) | | EPA Substance Registry System | 2,4,6-Tris(tert-butyl)phenol (732-26-3) |
| 2,4,6-Tri-tert-butylphenol Usage And Synthesis |
| Chemical Properties | Solid. Insoluble in water; soluble
in most organic solvents. Combustible. | | Uses | 2,4,6-Tri-tert-butylphenol is an antioxidant; used in preparation method of high-temperature resistant electromagnetic shielding electromagnetic bushing. | | Flammability and Explosibility | Nonflammable | | Biochem/physiol Actions | CDK5 is a member of the Cyclin-Dependent Kinase family that is most abundant in the mammalian brain. Active form of CDK5, which has also been called neuronal cdc2-like kinase, is a heterodimer of CDK5 and a 25 kDa protein which is derived proteolytically from a 35 kDa brain and neuron-specific protein and is essential for the kinase activity of CDK5. CDK5 has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes - from adhesion and motility, to synaptic plasticity and drug addiction. | | Purification Methods | Distil the phenol under reduced pressure and/or recrystallise it from n-hexane or several times from 95% EtOH until the EtOH solution is colourless [Balasubramanian & Bruice J Am Chem Soc 108 5495 1986]. It has also been purified by sublimation [Yuan & Bruice J Am Chem Soc 108 1643 1986, Wong et al. J Am Chem Soc 109 3428 1987]. Purification has also been achieved by passage through a silica gel column followed by recrystallisation from n-hexane [Kajii et al. J Phys Chem 91 2791 1987]. [Beilstein 6 III 2094, 6 IV 3539.] |
| 2,4,6-Tri-tert-butylphenol Preparation Products And Raw materials |
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