2-Naphthoic acid

CAS No.：93-09-4

Other grades of this product :

2-Naphthoic acid Basic information

Product Name:	2-Naphthoic acid
Synonyms:	2-Carboxynaphthalene;2-Maythic acid;2-maythicacid;2-Naphthoic acid, 99% 25GR;2-Naphthamine carbonic acid;2-Naphthoic acid ,99.5％;2-Naphthoic acid,99%;2-Naphthoic Acid (2-Naphthalenecarboxylic Acid)
CAS:	93-09-4
MF:	C11H8O2
MW:	172.18
EINECS:	202-217-8
Product Categories:	Naphthalene series;Building Blocks;C11 to C12;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Naphthalene derivatives;Organic acids;Absolute Configuration Determination (Exciton Chirality CD Method);Analytical Chemistry;Enantiomer Excess & Absolute Configuration Determination;Exciton Chirality CD Method (for Hydroxyl Groups);Organic Building Blocks;Pharmaceutical intermediates;bc0001
Mol File:	93-09-4.mol

2-Naphthoic acid Chemical Properties

Melting point	185-187 °C(lit.)
Boiling point	300 °C
density	1.08
refractive index	1.5520 (estimate)
Fp	205 °C
storage temp.	Sealed in dry,Room Temperature
solubility	alcohol: soluble
form	Powder
pka	4.17(at 25℃)
color	White to beige
PH	4.5 (H2O, 20℃)
Water Solubility	<0.5 g/L (20 C)
Merck	14,6382
BRN	972039
InChIKey	UOBYKYZJUGYBDK-UHFFFAOYSA-N
CAS DataBase Reference	93-09-4(CAS DataBase Reference)
NIST Chemistry Reference	2-Naphthalenecarboxylic acid(93-09-4)
EPA Substance Registry System	2-Naphthalenecarboxylic acid (93-09-4)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-24/25-36/373/39
WGK Germany	2
RTECS	QL1050000
TSCA	Yes
HS Code	29163900

MSDS Information

Provider	Language
2-Naphthalenecarboxylic acid	English
ACROS	English
SigmaAldrich	English
ALFA	English

2-Naphthoic acid Usage And Synthesis

Chemical Properties	Colorless solid
Uses	2-Naphthoic acid is an unprotected acid undergoes lithiation, e.g. with s-BuLi, by stereospecific 1,4-addition, providing a facile route to 1,2,2-trisubstituted 1,2-dihydronaphthalenes. It is also used as an intermediate in organic synthesis. The fluorescence spectra and electronic absorption of 2-naphthoic acid was studied.
Definition	ChEBI: 2-naphthoic acid is a naphthoic acid that is naphthalene carrying a carboxy group at position 2. It has a role as a xenobiotic metabolite and a mouse metabolite. It is a conjugate acid of a 2-naphthoate.
General Description	2-Naphthoic acid (NPA) is a noncompetitive N-methyl-D-aspartate (NMDA) receptor inhibitor. The fluorescence spectra and electronic absorption of 2-naphthoic acid was studied.
Purification Methods	Crystallise the acid from EtOH (4mL/g), aqueous 50% EtOH or Me2CO (m 185-186o). Dry it at 100o. The acid chloride has m 52-52o (from C6H6/pet ether) and b 160-162o/11mm [Hersberg & Carson Org Synth Coll Vol III 629 1955], the amide has m 192o (from EtOH), and the N-Methyl amide has m 109-109.5o (form C6H6). [Beilstein 9 H 656, 9 III 3174, 9 IV 2402.]

2-Naphthoic acid Preparation Products And Raw materials

Raw materials	1-Cyanonaphthalene
Preparation Products	2-Naphthylamine-->2-(3-BROMOPHENYL)-5-(2-NAPHTHYL)-1,3,4-OXADIAZOLE-->2-NAPHTHHYDRAZIDE-->2-Naphthoyl chloride-->2-Naphthalenemethanol-->1,3-DIHYDROXYNAPHTHALENE-->2,2'-DINAPHTHYL KETONE-->2-AMINO-1-BROMONAPHTHALENE-->5,6,7,8-TETRAHYDRO-2-NAPHTHOIC ACID-->1,2,3,4-TETRAHYDRO-2-NAPHTHOIC ACID-->4-TRIFLUOROMETHYLPHTHALIC ACID

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