Product

(R)-(+)-4-HYDROXY-2-PYRROLIDINONE

CAS No.：22677-21-0

Other grades of this product :

(R)-(+)-4-HYDROXY-2-PYRROLIDINONE Basic information

Product Name:	(R)-(+)-4-HYDROXY-2-PYRROLIDINONE
Synonyms:	(R)-(+)-4-HYDROXY-2-PYRROLIDINONE;(R)-4-HYDROXY-2-PYRROLIDINONE;(R)-4-HYDROXY-2-PYRROLIDONE;(R)-BETA-HYDROXY-GAMMA-BUTYROLACTAM;RHPD;2-PYRROLIDINONE, 4-HYDROXY-, (R);4-hydroxy-R-2-pyrrolidine;(r)-(+)-β-hydroxy-γ-butyrolactam
CAS:	22677-21-0
MF:	C4H7NO2
MW:	101.1
EINECS:
Product Categories:	Pyrrole&Pyrrolidine&Pyrroline;Amines;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Drug Intermediates
Mol File:	22677-21-0.mol

(R)-(+)-4-HYDROXY-2-PYRROLIDINONE Chemical Properties

Melting point	156-160 °C
Boiling point	363.6±35.0 °C(Predicted)
density	1.292±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Sparingly), Methanol (Slightly), Water (Sparingly)
pka	13.62±0.20(Predicted)
form	Powder
color	White to pale yellow
optical activity	[α]23/D +43°, c = 1 in ethanol
Water Solubility	Slightly soluble in water.
BRN	1524193
InChIKey	IOGISYQVOGVIEU-GSVOUGTGSA-N
CAS DataBase Reference	22677-21-0(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38-38-37-36
Safety Statements	26
WGK Germany	3
HS Code	29339900

MSDS Information

Provider	Language
SigmaAldrich	English

(R)-(+)-4-HYDROXY-2-PYRROLIDINONE Usage And Synthesis

Chemical Properties	white to light yellow crystal powde
Uses	The (R)-enantiomer intermediate in the preparation of Oxiracetam
Uses	(R)-(+)-4-Hydroxy-2-pyrrolidinone intermediate in the preparation of Oxiracetam. Also used as enantiomeric intermediate for the asymmetric single isomeric drugs including antitumor, anesthetic, antipasmodic, anti-inflammatory or anti-HIV activity products.

(R)-(+)-4-HYDROXY-2-PYRROLIDINONE Preparation Products And Raw materials

Raw materials

Butanoic acid, 4-amino-3-hydroxy-, ethyl ester, (3R)--->2-Pyrrolidinone, 1-[(1S)-1-phenylethyl]-4-(phenylmethoxy)-, (4R)-

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