Other grades of this product :
| Melting point | 84-86 °C(lit.) | | Boiling point | 465.9±55.0 °C(Predicted) | | density | 1.48±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | acetone: 50 mg/mL | | form | powder | | pka | 1.76±0.19(Predicted) | | color | White to Light Yellow | | BRN | 1548137 | | Stability: | Hygroscopic, Moisture Sensitive | | InChIKey | JWDFQMWEFLOOED-UHFFFAOYSA-N | | CAS DataBase Reference | 68181-17-9(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | F | 1-10 | | HS Code | 29333990 |
| Description | SPDP NHS ester is a heterobiofunctional crosslinker which can react with amine and sulfhydryl groups. SPDP NHS esters are membrane permeable therefore allowing them to funtion inside of cells. | | Chemical Properties | White Solid | | Uses | Important crosslinking reagent for the preparation of protein-protein and peptide-protein conjugates linked by disulfide bonds. | | Uses | 3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is useful for the preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.It has been used for antibody conjugation and as a protein cross-linker. | | Uses | A heterobifunctional cross-linker | | General Description | 3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is a heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thiol-disulfide exchange buffered at pH 8.0 (7.5-8.5). Alternately, this reagent may be used as a protected thiolating reagent following initial coupling and reduction of linker. It incorporates four atom linker. |
| SPDP Preparation Products And Raw materials |
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