3-TRIMETHYLSILYL-2-PROPYN-1-OL

CAS No.：5272-36-6

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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3-TRIMETHYLSILYL-2-PROPYN-1-OL Basic information

Product Name:	3-TRIMETHYLSILYL-2-PROPYN-1-OL
Synonyms:	3-TRIMETHYLSILYLPROPARGYL ALCOHOL, 98%3-TRIMETHYLSILYLPROPARGYL ALCOHOL, 98%3-TRIMETHYLSILYLPROPARGYL ALCOHOL, 98%;3-Trimethylsilyl-2-propyn-1-ol,99%;3-(triMethylsilyl)prop-2-yn-1-ol;3-Trimethylsilylpropargyl;3-(Trimethylsilyl)propargyl alcohol 99%;TIMTEC-BB SBB009061;TRIMETHYLSILYLPROPARGYL ALCOHOL;1-TRIMETHYLSILYLPROPARGYL ALCOHOL
CAS:	5272-36-6
MF:	C6H12OSi
MW:	128.24
EINECS:	226-094-5
Product Categories:	Acetylenic Alcohols & Their Derivatives;Ethynylsilanes;Si (Classes of Silicon Compounds);Si-(C)4 Compounds;Silicon Compounds (for Synthesis);Synthetic Organic Chemistry;Acetylenes
Mol File:	5272-36-6.mol

3-TRIMETHYLSILYL-2-PROPYN-1-OL Chemical Properties

Melting point	63.5-65.0 °C
Boiling point	76 °C11 mm Hg(lit.)
density	0.865 g/mL at 25 °C(lit.)
refractive index	n20/D 1.451(lit.)
Fp	152 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Benzene (Sparingly)
pka	13.71±0.10(Predicted)
form	Liquid
color	Clear yellow
Specific Gravity	0.865
Water Solubility	Not miscible with water.
Sensitive	Moisture Sensitive
Hydrolytic Sensitivity	4: no reaction with water under neutral conditions
BRN	1902505
InChIKey	ZVGCJDPEKKEYES-UHFFFAOYSA-N
CAS DataBase Reference	5272-36-6(CAS DataBase Reference)
NIST Chemistry Reference	3-Trimethylsilylpropargyl alcohol(5272-36-6)
EPA Substance Registry System	2-Propyn-1-ol, 3-(trimethylsilyl)- (5272-36-6)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	23-24/25-37/39-26
RIDADR	2810
WGK Germany	3
F	8-10
TSCA	Yes
HazardClass	6.1
PackingGroup	III
HS Code	29319090

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English
ALFA	English

3-TRIMETHYLSILYL-2-PROPYN-1-OL Usage And Synthesis

Chemical Properties	clear yellow liquid
Uses	Trimethylsilylpropargyl alcohol is used as a reagent to synthesize Isbogrel, a Thromboxane A 2 (TXA 2) synthase inhibitor and also a TXA 2 receptor antagonist that has potential to treat asthma.

3-TRIMETHYLSILYL-2-PROPYN-1-OL Preparation Products And Raw materials

Raw materials	Bis[tris(trimethylsilyl)silyl]zinc-->Tetrahydro-2-[[3-(trimethylsilyl)-2-propyn-1-yl]oxy]-2H-Pyran-->PROPARGYLOXYTRIMETHYLSILANE-->TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN-->1-trimethylsilyloxy-3-trimethylsilylprop-2-yne-->PHENYLETHYNYLMAGNESIUM BROMIDE-->1-PHENYL-2-(TRIMETHYLSILYL)ACETYLENE-->Bromoethane-->Dichlorodimethylsilane-->Propargyl alcohol
Preparation Products	3-BROMO-1-(TRIMETHYLSILYL)-1-PROPYNE-->1-Trimethylsilyl-1-butyne-->3-TRIMETHYLSILYLPROPYNAL

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