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| 4-Mercaptopyridine Basic information |
| 4-Mercaptopyridine Chemical Properties |
| Melting point | 182-189 °C | | Boiling point | 194.0±13.0 °C(Predicted) | | density | 1.161 (estimate) | | refractive index | 1.5605 (estimate) | | storage temp. | 2-8°C | | solubility | DMSO, Methanol | | pka | pK1:1.43(＋1);pK2:8.86(0) (20°C) | | form | Crystalline Powder | | color | Yellow to yellow-green or brown | | InChIKey | FHTDDANQIMVWKZ-UHFFFAOYSA-N | | CAS DataBase Reference | 4556-23-4(CAS DataBase Reference) | | NIST Chemistry Reference | 4-Pyridinethiol(4556-23-4) |
| 4-Mercaptopyridine Usage And Synthesis |
| Chemical Properties | 4-Mercaptopyridine is Yellow to light yellow crystalline powder
| | Uses | 4-Mercaptopyridine is a pyridine derivative used as a redox reagents for the in vitro refolding of a recombinantly expressed single-chain Fv fragment (scFvOx). Used in studies along with thiosulfate to measure alliinase activity.
| | Uses | mercaptopyridine is also known as sodium pyrithione. It is a preservative that is not commoly used. | | Uses | 4-Mercaptopyridine was used as a probe molecule to study the performance of the gold nanorod (AuNR)/polycaprolactone (PCL) fibrous mesh. | | Purification Methods | Purify the thiol by dissolving ~45g in boiling H2O (100mL) (charcoal), filter and precipitate it by adding 50% aqueous NaOH (~80mL) to pH ~6. Dissolve the precipitate in EtOH, evaporate it to dryness, then crystallise it from boiling EtOH (~100mL, charcoal) to give yellow flat hexagonal plates (m 186o). It sublimes readily in vacuo. [King & Ware J Chem Soc 873 1939.] The picrate forms yellow needles from H2O with m 222o(dec). The 4-methylmercaptopyridine derivative crystallises from pet ether (m 47o , also 44-45o was reported, with a pK2 0 of 5.97) and was prepared by treatment with MeI/NaOH. Its picrate has m 2 4 5o (from H2O, MeOH or EtOH). The N-methyl-4-pyridinethiol derivative has m 168.5-170o (from EtOH), a pK2 0 of 1.30 and is soluble in CHCl3. [Albert & Barlin J Chem Soc 2384 1959, Beilstein 21 II 35, 22 III/IV 373, 22/7 V 147.] |
| 4-Mercaptopyridine Preparation Products And Raw materials |
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