2-Iodopyridine

CAS No.：5029-67-4

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2-Iodopyridine Basic information

Product Name:	2-Iodopyridine
Synonyms:	2-Iodopyridine(stabilizedwithCopperchip);2-lodopyridine;2-IODOPYRIDINE, 95+%;2-IODOPYRIDINE;2-Pyridyl iodide;2-Iodopyridine 2-Iodopyridine (stabilized with Na2S2O3);2-Iodopyridine 98%
CAS:	5029-67-4
MF:	C5H4IN
MW:	205
EINECS:
Product Categories:	Heterocycle-Pyridine series;Halides;Pyridines;Pyridine;Halopyridines;Iodopyridines;C5Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks
Mol File:	5029-67-4.mol

2-Iodopyridine Chemical Properties

Melting point	118-120℃
Boiling point	52 °C (lit.)
density	1.928 g/mL at 25 °C (lit.)
refractive index	n20/D 1.6320(lit.)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	Solid
pka	pK1:1.82(＋1) (25°C)
color	Pale yellow
Water Solubility	Slightly soluble in water.
Sensitive	Light Sensitive
InChIKey	CCZWSTFVHJPCEM-UHFFFAOYSA-N
CAS DataBase Reference	5029-67-4(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
Hazard Note	Irritant
HS Code	29333990

MSDS Information

Provider	Language
2-Iodopyridine	English
SigmaAldrich	English

2-Iodopyridine Usage And Synthesis

Chemical Properties	Light yellow liquid
Uses	2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane.2-Iodopyridine is a halogenated building block. It is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors.
Uses	2-Iodopyridine is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors.
Reactions	2-Iodopyridine and 3-alkoxy-2-iodopyridines are oxidized by DMDO to give PyIO2 , which serve as oxidants for alcohols and sulfides.In palladium-catalyzed aminocarbonylation of 2-iodopyridine, 3-iodopyridine and iodopyrazine were coupled with CO and various primary and secondary amines. The biologically relevant N-substituted nicotinamides and 3-pyridyl-glyoxylamides were obtained from 3-iodopyridine as a result of simple and double carbon monoxide insertions, respectively. The chemoselectivity towards the ketoamide can be increased by the elevation of CO pressure. On the other hand, N-alkyl and N-aryl-carboxamides were obtained exclusively from CO pressure of 1 to 90 bar by using 2-iodopyridine and iodopyrazine.Pd-catalyzed aminocarbonylation of 2-iodopyridine and 3-iodopyridine with primary and secondary amines.
Synthesis Reference(s)	Tetrahedron Letters, 31, p. 6757, 1990 DOI: 10.1016/S0040-4039(00)97163-6
General Description	2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane.

2-Iodopyridine Preparation Products And Raw materials

Raw materials	Hydriodic acid-->2-Bromopyridine
Preparation Products	2-(2-Pyridyl)benzoxazole-->2,2'-BITHIOPHENE-->Methyl picolinate-->2-PYRAZOL-1-YL-PYRIDINE-->DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER-->2-Dimethylaminopyridine-->2-Methylthiopyridine-->2-Benzoylpyridine-->2-Benzylaminopyridine-->2-Pyridinepropanol-->Diphenyl-2-pyridylphosphine-->2,2'-Bipyridine

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