Product

alpha-Angelica lactone

CAS No.：591-12-8

Other grades of this product :

alpha-Angelica lactone Basic information

Product Name:	alpha-Angelica lactone
Synonyms:	3-PENTEN-4-OLIDE;4-HYDROXY-3-PENTANOIC ACID GAMMA-LACTONE;4-HYDROXY-3-PENTENOIC ACID GAMMA-LACTONE;4-HYDROXY-3-PENTENOIC ACID G-LACTONE;4-HYDROXY-3-PENTENOIC ACID LACTONE;2,3-Dihydro-5-methyl-2-furanone;3-Pentenoic acid, 4-hydroxy-, gamma-lactone;4-hydroxy-3-pentenoicacigamma-lactone
CAS:	591-12-8
MF:	C5H6O2
MW:	98.1
EINECS:	209-701-8
Product Categories:	Miscellaneous Natural Products
Mol File:	591-12-8.mol

alpha-Angelica lactone Chemical Properties

Melting point	13-17 °C(lit.)
Boiling point	55-56 °C12 mm Hg(lit.)
density	1.092 g/mL at 25 °C(lit.)
refractive index	n20/D 1.448(lit.)
FEMA	3293 \| 4-HYDROXY-3-PENTENOIC ACID LACTONE
Fp	155 °F
storage temp.	2-8°C
solubility	Chloroform, Ethyl Acetate
form	Oil
pka	pK1:4.3 (25°C)
Specific Gravity	1.101.092
color	Clear Light Yellow
Water Solubility	5 g/100 mL (25 ºC)
JECFA Number	221
Merck	14,647
BRN	108394
CAS DataBase Reference	591-12-8(CAS DataBase Reference)
NIST Chemistry Reference	2(3H)-Furanone, 5-methyl-(591-12-8)
EPA Substance Registry System	5-Methyl-2(3H)-furanone (591-12-8)

Safety Information

Safety Statements	24/25
RIDADR	NA 1993 / PGIII
WGK Germany	2
RTECS	LU5075000
F	10-21
TSCA	Yes
HS Code	29322090
Toxicity	LD50 orl-mus: 2800 mg/kg DCTODJ 3,249,80

MSDS Information

Provider	Language
alpha-Angelica lactone	English
SigmaAldrich	English
ACROS	English
ALFA	English

alpha-Angelica lactone Usage And Synthesis

Chemical Properties	clear colorless to straw yellow liquid
Chemical Properties	α-Angelica lactone has a sweet, herbaceous odor reminiscent of tobacco.
Occurrence	Reported found in grape, white bread, soy bean and licorice.
Uses	alpha-Angelicalactone acts as acancer chemopreventive agent. It is used in the synthesis of glutathione and the activity of glutathione-S-transferase and UDP-glucunonosyltransferase detoxification enzymes in esophagus, stomach, intestine, and liver. It is used in oral care formulations to round out mint notes and in coffee flavors.
Preparation	By dry distillation of levulinic acid
Taste threshold values	Taste characteristics at 100 ppm: sweet, creamy, coconut, vanilla hay and coumarin-like nuances
General Description	α-Angelica lactone, a cyclic lactone that occurs naturally in tobacco, is generally used in tobacco flavoring.
Biochem/physiol Actions	Plant-derived cancer chemopreventive agent. Increases the synthesis of glutathione and the activity of glutathione-S-transferase and UDP-glucunonosyltransferase detoxification enzymes in esophagus, stomach, intestine, and liver.
Safety Profile	Moderately toxic by ingestion andintraperitoneal routes. When heated to decomposition itemits acrid smoke and irritating fumes.

alpha-Angelica lactone Preparation Products And Raw materials

Preparation Products

5-methylenefuran-2(5H)-one-->2-Ethylfuran

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