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| 4-Bromo-2-fluoroaniline Basic information |
| 4-Bromo-2-fluoroaniline Chemical Properties |
| Melting point | 40-42 °C | | Boiling point | 103-108 °C (13 mmHg) | | density | 1.6196 (rough estimate) | | refractive index | 1.4710 (estimate) | | Fp | 220 °F | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 2.50±0.10(Predicted) | | form | Crystalline Mass, Powder, Crystals and/or Chunks | | color | Beige to light brown to brown-gray or gray | | BRN | 2081089 | | Stability: | Stable. Incompatible with acid chlorides, acid anhydrides, strong acids, strong oxidizing agents. | | InChIKey | GZRMNMGWNKSANY-UHFFFAOYSA-N | | CAS DataBase Reference | 367-24-8(CAS DataBase Reference) | | NIST Chemistry Reference | 4-Bromo-2-fluoroaniline(367-24-8) |
| 4-Bromo-2-fluoroaniline Usage And Synthesis |
| Chemical Properties | solid | | Uses | 4-Bromo-2-fluoroaniline can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes. | | Uses | 4-Bromo-2-fluoroaniline was used in synthesis of 4-amino-3-fluorophenyl boronic acid. It was also used in chemical modification and synthesis of boronic acid derivatives for ultraviolet-visible titration. | | Synthesis | To a stirred solution of 4-bromo-2-fluoro-l -nitrobenzene (10 g, 45.5 mmol) in EtOH (50 mL)AVater (20 mL) was added iron (12.7 g, 230 mmol) and NH4C1 (24.3 g, 455 mmol). The reaction mixture was stirred at 90 °C for 2 h. After 2 h the reaction mixture was filtered over Celite. The filter cake was washed with EtOH (300 mL), and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography (S1O2, Petroleum ether/EtOAc=10: l to 5: 1) to afford 4-bromo-2-fluoroaniline. |
| 4-Bromo-2-fluoroaniline Preparation Products And Raw materials |
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