| Nalpha-Cbz-L-Arginine Basic information |
| Product Name: | Nalpha-Cbz-L-Arginine |
| Synonyms: | n2-[(phenylmethoxy)carbonyl]-l-arginin;BenzyloxycarbonylLarginine;N(alpha)-Benzyloxycarbonyl-L-arginine~Z-Arg-OH;Na-Benzyloxycarbonyl-L-arginine;na-cbz-L-arginine free acid;N2-[(phenylmethoxy)carbonyl]-L-arginine;Nα-Z-L-Arginine;N2-Carbobenzyloxy-L-arginine |
| CAS: | 1234-35-1 |
| MF: | C14H20N4O4 |
| MW: | 308.33 |
| EINECS: | 214-973-6 |
| Product Categories: | Arginine [Arg, R];Z-Amino Acids and Derivatives;PROTECTED AMINO ACID & PEPTIDES;Amino Acids;Amino Acids (N-Protected);Biochemistry;Cbz-Amino Acids;Z-Amino acid series |
| Mol File: | 1234-35-1.mol |
| Nalpha-Cbz-L-Arginine Chemical Properties |
| Melting point | 171-174 °C (dec.)(lit.) |
| alpha | -11 º (c=0.5, 0.5N HCl 24 ºC) |
| Boiling point | 448.73°C (rough estimate) |
| density | 1.1765 (rough estimate) |
| refractive index | -10 ° (C=5.5, 0.2mol/L HCl) |
| storage temp. | 2-8°C |
| solubility | DMSO, Water |
| form | Solid |
| pka | 3.90±0.21(Predicted) |
| color | White |
| optical activity | [α]20/D 9±1°, c = 5% in 1 M HCl |
| BRN | 2169267 |
| CAS DataBase Reference | 1234-35-1(CAS DataBase Reference) |
| EPA Substance Registry System | L-Arginine, N2-[(phenylmethoxy)carbonyl]- (1234-35-1) |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 24/25-36-26-S24/25 |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29252900 |
| MSDS Information |
| Provider | Language |
|---|---|
| Nalpha-Cbz-L-Arginine | English |
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| Nalpha-Cbz-L-Arginine Usage And Synthesis |
| Chemical Properties | white powder |
| Uses | Z-L-Arginine is used in the synthesis of renin inhibitors containing phosphorous acid derivatives at the scissile bond. Also used in the synthesis of a peptide deformylase inhibitor BB-3497. |
| Nalpha-Cbz-L-Arginine Preparation Products And Raw materials |
| Raw materials | N(alpha)-carbobenzoxyarginine-4-nitroanilide-->Z-ARG(NO2)-OH-->Z-ORN-OH-->H-PHE-NH2-->L(+)-Arginine-->Cyanamide-->Benzyl chloroformate-->Benzyl alcohol-->4-Nitroaniline |
| Preparation Products | N-Phospho-L-arginine-->PHOSPHO-L-ARGININE SODIUM-->Z-ARG(Z)2-OH-->4-Nitrophenol |
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