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| Temocapril hydrochloride Basic information |
| Product Name: | Temocapril hydrochloride | | Synonyms: | TEMOCAPRIL HYDROCHLORIDE;Temocapril HCl and intermediates;Acecol;CS-622;1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, monohydrochloride, (2S,6R)- (9CI);1,4-Thiazepine-4(5H)-acetic acid, 6-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, monohydrochloride, [2S-[2a,6b(R*)]]-;Temocapril Hcl;TemocarpileHCL | | CAS: | 110221-44-8 | | MF: | C23H28N2O5S2.ClH | | MW: | 513.076 | | EINECS: | 1312995-182-4 | | Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors | | Mol File: | 110221-44-8.mol |
| Temocapril hydrochloride Chemical Properties |
| Melting point | 196-2000C (dec) | | alpha | 25D +47.7° (c = 1 in DMF) | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | DMF (Slightly), DMSO (Slightly), Methanol (Slightly) | | form | Solid | | color | White to Off-White | | CAS DataBase Reference | 110221-44-8(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | Toxicity | LD50 in mice, rats, dogs (mg/kg): >5000, >5000, >800 orally (Koike) |
| Temocapril hydrochloride Usage And Synthesis |
| Description | Temocapril is a novel ACE inhibitor marketed in Japan for the treatment of
hypertension. Temocapril is three times more potent than enalapril by oral
administration, and has a long duration of action. It is characterized by a rapid onset
of action resulting from a fast conversion of temocapril to the active metabolite
diacid. Unlike most ACE inhibitors which are excreted mainly through the kidneys,
temocapril is excreted predominantly through the biliary route indicating that
temocapril is especially useful for treating hypertensive patients with renal
dysfunction. The potential usefulness of temocapril in the treatment of congestive
heart failure has been reported. | | Chemical Properties | White To Off-White Solid | | Originator | Sankyo (Japan) | | Uses | Angiotensin-converting enzyme (ACE) inhibitor. Hydrolyzed in vivo to the active diacid metabolite. | | Uses | Angiotensin-converting enzyme (ACE) inhibitor. Hydrolyzed in vivo to the active diacid metabolite | | Uses | angiotensin-converting enzyme inhibitor (ACE-I) | | Brand name | Acecol |
| Temocapril hydrochloride Preparation Products And Raw materials |
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