(R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid

CAS No.：181289-33-8

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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(R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid Basic information

Uses Sources

Product Name:	(R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid
Synonyms:	(r)-(-)-3-(2-amino-2-oxoethyl)-5-methylhexanoic acid;(r)-(-)-3-carbamoymethyl-5-methylhexanoic acid;INTERMEDIATE OF PREGABALIN;(3R)-3-(2-AMino-2-oxoethyl)-5-Methylhexanoic Acid;(R)-3-(2-AMINO-2-OXOETHYL)-5-METHYLHEXANOIC ACID:99+%;3-CarbaMoyl Mehyl-5-Methyl Hexanoic Acid;Pregabalin IMpurity III;Hexanoic acid,3-(2-aMino-2-oxoethyl)-5-Methyl-,(3R)-
CAS:	181289-33-8
MF:	C9H17NO3
MW:	187.24
EINECS:	605-923-8
Product Categories:	Aliphatics, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;intermidiate of Pregablin;Starting Raw Materials & Intermediates
Mol File:	181289-33-8.mol

(R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid Chemical Properties

Melting point	128-133°C
Boiling point	401.9±28.0 °C(Predicted)
density	1.080±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
pka	4.68±0.10(Predicted)
CAS DataBase Reference	181289-33-8(CAS DataBase Reference)

Safety Information

MSDS Information

(R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid Usage And Synthesis

Uses	(R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid is a useful chemical intermediate for manufacturing of the anticonvulsant drug, Pregabalin^{1, 2}.
Sources	https://quod.lib.umich.edu/a/ark/5550190.0011.a22?rgn=main;view=fulltext https://www.researchgate.net/publication/269660675_Synthesis_and_characterization_of_impurities_of_an_anticonvulsant_drug_Pregabalin
Chemical Properties	White Solid
Uses	An Impurity of the anti-convulsant (S)-Pregabalin (P704790).

(R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid Preparation Products And Raw materials

Raw materials

Hexanoicacid, 3-(2-amino-2-oxoethyl)-5-methyl-, (3S)--->3-Carbamoymethyl-5-methylhexanoic acid-->(3S)-3-(2-methoxy-2-oxoethyl)-5-methylhexanoic acid

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