Other grades of this product :
| Nestoron Basic information |
| Product Name: | Nestoron | | Synonyms: | ST 1435;NESTORONE;NESTORON;17-Hydroxy-16-methylene-19-norpregn-4-ene-3,20-dione acetate;Elcometrine;17-(ACETYLOXY)-16-METHYLENE-19-NORPREGN-4-ENE-20-DIONE;16-Methylene-17-hydroxy-19-norpregn-4-ene-3,20-dione acetate;16-Methylene-17-alpha-acetoxy-19-nor-4-pregnene-3,20-dione | | CAS: | 7759-35-5 | | MF: | C23H30O4 | | MW: | 370.48 | | EINECS: | | Product Categories: | API | | Mol File: | 7759-35-5.mol |
| Nestoron Chemical Properties |
| Melting point | 178-179° | | alpha | D21 -105° (c = 1.2 in chloroform) | | Boiling point | 420.37°C (rough estimate) | | density | 1.0550 (rough estimate) | | refractive index | 1.4433 (estimate) | | storage temp. | 2-8°C | | solubility | DMSO: soluble5mg/mL, clear | | form | powder | | color | white to beige | | InChIKey | CKFBRGLGTWAVLG-GOMYTPFNSA-N |
| Nestoron Usage And Synthesis |
| Uses | Segesterone Acetate has been used to study the: comparison of androgenic and estrogenic properties of progestins used in contraception and hormone therapy; impact on hepatic estrogen-sensitive proteins by 1-yr contraceptive vaginal ring delivering Nestorone and ethinyl estradiol. | | Pharmacokinetics | Elcometrine is a member of the 19-norprogesterone class of pr ogestins. when administered subcuta neously (implant), intravaginally (vaginal ring), or transdermally, elcometrine is an exceptionally potent progestin. It is 100-fold more potent when administered subcutaneously than when delivered orally. Its oral bioavaiability is only 10%，with a half life of just 1 to 2 hours because of rapid metabolism. The C16 methylene functionality substantially increases its affinity for the progesterone receptor. | | Clinical Use | Because of its antiestrogenic action, elcometrine also can be administered transdermally along with estradiol as a treatment for menopausal symptoms . |
| Nestoron Preparation Products And Raw materials |
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