Other grades of this product :
| 2,2-bis(4-fluorophenyl)-2-phenyl-acetamide Basic information |
| Product Name: | 2,2-bis(4-fluorophenyl)-2-phenyl-acetamide | | Synonyms: | 2,2-bis(4-fluorophenyl)-2-phenyl-acetamide;Benzeneacetamide, 4-fluoro-a-(4-fluorophenyl)-a-phenyl-;4-Fluoro-alpha-(4-fluorophenyl)-alpha-phenylbenzeneacetamide;4-Fluoro-A-(4-Fluorophenyl)-A-Phenyl-BenzeneacetaMide;ICA 17043;Senicapoc;ICA-17043;ICA 17043;ICA17043;Benzeneacetamide, 4-fluoro-α-(4-fluorophenyl)-α-phenyl- | | CAS: | 289656-45-7 | | MF: | C20H15F2NO | | MW: | 323.34 | | EINECS: | | Product Categories: | | Mol File: | 289656-45-7.mol |
| 2,2-bis(4-fluorophenyl)-2-phenyl-acetamide Chemical Properties |
| Melting point | 180-181 °C(Solv: hexane (110-54-3); dichloromethane (75-09-2)) | | Boiling point | 460.7±45.0 °C(Predicted) | | density | 1.250±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | pka | 15.41±0.50(Predicted) |
| 2,2-bis(4-fluorophenyl)-2-phenyl-acetamide Usage And Synthesis |
| Description | Senicapoc is an inhibitor of intermediate conductance calcium-activated potassium (IKCa1/KCa3.1) channels. It inhibits rubidium efflux from and dehydration of isolated human red blood cells (RBCs) induced by the calcium ionophore A23187 (; IC50s = 11 and 30 nM, respectively). Senicapoc (10 mg/kg twice per day) reduces IKCa1/KCa3.1 channel activity, increases potassium levels in RBCs, and decreases erythrocyte density in the SAD transgenic mouse model of sickle cell disease. It inhibits IL-2, IFN-γ, IL-12, and IL-17A production in CD3+ T cells stimulated with phorbol 12-myristate 13-acetate (PMA; ) and ionomycin (Item Nos. 10004974 | 11932) when used at a concentration of 1 μM. Senicapoc (100 mg/kg) increases the paw withdrawal threshold in a rat model of chronic constriction injury (CCI) of the sciatic nerve. | | Uses | Treatment of disorders mediated by a calcium activated intermediate conductance potassium ion channel antagonist. |
| 2,2-bis(4-fluorophenyl)-2-phenyl-acetamide Preparation Products And Raw materials |
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