4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide

CAS No.：119018-29-0

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4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide Basic information

Product Name:	4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide
Synonyms:	n-[2-[4-(aminosulfonyl)phenyl]ethyl]-3-ethyl-2,5-dihydro-4-methyl-2-oxo-1h-pyrrole-1-carboxamide;N-[2-[4-(AMINOSULFONYL)PHENYL]ETHYL]-3-ETHYL-4-METHYL-2-OXO-1H-PYRROLE-1-CARBOXAMIDE;4-(2-(3-Ethyl-4-Methyl-2-Oxo-3-Pyrroline-1-Carboxamido)-Ethyl)-Benzenesulfonyl A;4-[2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamidoethyl]benzenesulfonamide;N-[4-2-(3-Ethyl-4-Methyl-2-Oxo-3-Pyrroline-1-Carboxamido)-Ethyl]Benzensulfonamide;4-[2-(3-Ethyl-4-Methyl-2-Oxo-3-Pyrroline-1-Carboxamide)Ethyl]Sulphonamide;Glimepiride Impurity 2(Glimepiride EP Impurity B);Glimepiride sulfonamide
CAS:	119018-29-0
MF:	C16H21N3O4S
MW:	351.42
EINECS:	411-850-0
Product Categories:	Glimepiride;Aromatics;PHARMACEUTICAL INTERMEDIATES;Aromatics Compounds;Heterocycles;Sulfur & Selenium Compounds
Mol File:	119018-29-0.mol

4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide Chemical Properties

Melting point	177-179?C
density	1.304
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly, Sonicated)
form	neat
pka	10.16±0.10(Predicted)
color	White to Off-White
InChIKey	AJEMFZRCUKJSES-UHFFFAOYSA-N
CAS DataBase Reference	119018-29-0(CAS DataBase Reference)

Safety Information

Risk Statements	52/53
Safety Statements	61
HS Code	2935909550

MSDS Information

4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide Usage And Synthesis

Chemical Properties	White Solid
Uses	Intermediate for the preparation of Glimepiride
Uses	4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide (Glimepiride EP Impurity B) is an intermediate for the preparation of Glimepiride.

4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide Preparation Products And Raw materials

Raw materials

4-(2-Aminoethyl)benzenesulfonamide-->4-{2-{[(3-Ethyl-2,5-dihydro-4-methyl-2-oxo-1H-pyrrol-1-yl)-carbonyl]-amino}-ethyl}-benzenesulfonyl chloride-->1-acetyl-3-ethyl-4-Methyl-1H-pyrrol-2(5H)-one-->Butanoic acid, 3-cyano-2-ethyl-3-hydroxy-, ethyl ester-->Ethyl 2-ethylacetoacetate-->3-Ethyl-4-methyl-3-pyrrolin-2-one-->3-Ethyl-2,5-Dihydro-4-Methyl-2-Oxo-N-(2-Phenylethyl)-1h-Pyrrole-1-Carboxamide-->Phenethyl isocyanate-->Phenethyl chloride

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