4-FLUOROPHENYLMAGNESIUM BROMIDE

CAS No.：352-13-6

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

View the full Disclaimer

Other grades of this product :

4-FLUOROPHENYLMAGNESIUM BROMIDE Basic information

Product Name:	4-FLUOROPHENYLMAGNESIUM BROMIDE
Synonyms:	4-FLUOROPHENYLMAGNESIUM BROMIDE;4-FLUOROPHENYLMAGNESIUM BROMIDE, 2M IN DIETHYL ETHER;4-FLUOROPHENYLMAGNESIUM BROMIDE, 2.0M SO LUTION IN DIETHYL ETHER;4-FLUOROPHENYLMAGNESIUM BROMIDE SOL., ~2 .0 M IN DIETHYL ET;4-FLUOROPHENYLMAGNESIUM BROMIDE, 1.0M SO LUTION IN TETRAHYDROFURAN;4-FLUOROPHENYLMAGNESIUM BROMIDE SOL., ~1 M IN THF;4-Fluorophenylmagnesium Bromide 1.0 M In Tetrahydrofuran;4-Fluorophenylmagnesium Bromide 2.0 M In Diethyl Ether
CAS:	352-13-6
MF:	C6H4BrFMg
MW:	199.31
EINECS:	627-087-3
Product Categories:	Grignard Reagents;Aryl;Organometallic Reagents;Grignard Reagent
Mol File:	352-13-6.mol

4-FLUOROPHENYLMAGNESIUM BROMIDE Chemical Properties

Melting point	5 °C
Boiling point	66°C
density	1.043 g/mL at 25 °C
Fp	−40 °F
storage temp.	Flammables + water-Freezer (-20°C)e area
form	Solution
color	Clear yellow to red-brown
Water Solubility	It reacts violently with water.
Sensitive	Air & Moisture Sensitive
BRN	636802
InChIKey	QYBFFRXNNFXREA-UHFFFAOYSA-M
CAS DataBase Reference	352-13-6
EPA Substance Registry System	Magnesium, bromo(4-fluorophenyl)- (352-13-6)

Safety Information

Hazard Codes	F+,C,F
Risk Statements	12-14-22-34-66-67-11-40-37-19
Safety Statements	16-26-36/37/39-43-45-7/8-33-8-7
RIDADR	UN 2924 3/PG 2
WGK Germany	1
F	10-21
TSCA	Yes
HazardClass	3
PackingGroup	II
HS Code	29319090

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English

4-FLUOROPHENYLMAGNESIUM BROMIDE Usage And Synthesis

Chemical Properties	clear yellow to red-brown solution
Uses	4-Fluorophenylmagnesium bromide is used as a reagent for the introduction of the 4-Fluorophenyl group.
Uses	4-Fluorophenylmagnesium bromide solution (Grignard reagent) can be used as a reagent in the synthesis of: Useful key intermediate in the synthesis of paroxetine. Arylsulfides via cross-coupling reaction with thiols. 4-Arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as androgen receptor antagonists. Grignard intermediate for preparing aprepitant.

4-FLUOROPHENYLMAGNESIUM BROMIDE Preparation Products And Raw materials

Preparation Products

4-Fluorobenzeneboronic acid-->4-(4-FLUORO-PHENYL)-PIPERIDIN-4-OL HYDROCHLORIDE-->1-Fluoro-4-(1-methylethenyl)benzene-->2-(4-Fluorophenyl)-pyrrolidine-->4-Fluoro-1,1'-biphenyl-->BIS-(4-FLUORO-PHENYL)-PHENYL-METHANOL

Welcome！

Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.

NO. 18 ,Wujiang Road, Wulidian Street, Jiangbei District, Chongqing
+86-23-6139-8061 +86-13650506873
danny@chemdad.com sales@chemdad.com
www.chemdad.com
WhatsApp +86-13650506873