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| 4-THIOURIDINE Basic information |
| Product Name: | 4-THIOURIDINE | | Synonyms: | 1-((2R,3R,4S,5R);-4-thioxo-3,4-dihydropyrimidin-2(1H);THIOURIDINE, 4-;4-THIOURIDINE;thiouridine;4-thiouridineapprox.;4-Thio-D-uridine;1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-4-thioxo-3,4-dihydropyriMidin-2(1H)-one | | CAS: | 13957-31-8 | | MF: | C9H12N2O5S | | MW: | 260.27 | | EINECS: | 237-735-3 | | Product Categories: | Biochemicals and Reagents;Nucleoside Analogs;Nucleosides, Nucleotides, Oligonucleotides;Bases & Related Reagents;Nucleotides;Sulfur & Selenium Compounds | | Mol File: | 13957-31-8.mol |
| 4-THIOURIDINE Chemical Properties |
| Melting point | 139-140℃ (ethanol ) | | density | 1.72±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) | | form | crystalline | | pka | 4.75±0.20(Predicted) | | color | light yellow | | Water Solubility | Soluble in water (20 mg/ml), and methanol (10 mg/ml). | | InChIKey | ZLOIGESWDJYCTF-XVFCMESISA-N | | CAS DataBase Reference | 13957-31-8(CAS DataBase Reference) |
| Safety Statements | 24/25 | | WGK Germany | 3 | | HS Code | 29349990 |
| 4-THIOURIDINE Usage And Synthesis |
| Description | 4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling. The crosslinking thio moiety is attached directly to the nucleotide base, thus 4-SU differs from uridine only by a single sulfur substitution. This offers the advantage of incorporating into an RNA chain with minimal structural perturbation and with similar base-pairing properties, reducing the likelihood that substitution will impair RNA interactions or activities. | | Uses | Nucleotide analogue, essential for cell growth in certain bacterial species. This compound is also able to chelate with certain metal ions, and in tRNA it can act as a built-in antiphotomutagenic agent that protects Escherichia coli cells against mutagenesis. | | Uses | 4-Thiouridine is a photoreactive (crosslinking) uridine analogue that upon phosphorylation to 4-thioUTP may be incorporated into RNA structures. 4-Thiouridine may be used to study the specificity and kinetics of uridine-cytidine kinases. | | Uses | 4-Thiouridine is a constituent of several transfer RNA's. 4-Thiouridine is a thionucleobase used as an antisense agent. Widely used for RNA analysis including RNA-RNA cross coupling and RNA labelling. 4-Thiouridine is a photoreactive (crosslinking) uridine analogue that upon phosphorylation to 4-thioUTP may be incorporated into RNA structures. 4-Thiouridine may be used to study the specificity and kinetics of uridine-cytidine kinases. 4-Thio Uridine is typically used to modify oligos slated for RNA, or RNA-protein, structural studies. A 4-thio-rU modified RNA pentamer was used to study the effect of this modification on codon-anticodon interaction when it is in the wobble position of tRNA. | | Definition | ChEBI: A thiouridine in which the oxygen replaced by sulfur is that at C-4. | | General Description | 4-Thiouridine is a photoreactive uridine analog. | | Biochem/physiol Actions | 4-Thiouridine plays a role in assessing nascent RNA synthesis. It also enhances site-specific crosslinking. 4-Thiouridine also acts as a photoaffinity probe due to its stability even while lacking specific photoactivation. It can also be incorporated into RNAs. |
| 4-THIOURIDINE Preparation Products And Raw materials |
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