3-Fluoroaniline

CAS No.：372-19-0

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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3-Fluoroaniline Basic information

Product Name:	3-Fluoroaniline
Synonyms:	3-fluoro-anilin;Aniline, 3-fluoro-;Aniline, m-fluoro-;1,3-fluorobenzenamine;3-Fluoranilin;Afatinib Impurity 95;3-Fluoroaniline,98+%;3-FLUOROANILINE,99%
CAS:	372-19-0
MF:	C6H6FN
MW:	111.12
EINECS:	206-747-0
Product Categories:	Amines;Aryl Fluorinated Building Blocks;Building Blocks;C6;Chemical Synthesis;Fluorinated Building Blocks;Anilines, Aromatic Amines and Nitro Compounds;Fluorobenzene;Anilines, Amides & Amines;Fluorine Compounds;Nitrogen Compounds;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;amine \| alkyl Fluorine
Mol File:	372-19-0.mol

3-Fluoroaniline Chemical Properties

Melting point	-2°C
Boiling point	186 °C756 mm Hg(lit.)
density	1.156 g/mL at 25 °C(lit.)
refractive index	n20/D 1.542(lit.)
Fp	171 °F
storage temp.	Store below +30°C.
solubility	8g/l (calculated)
pka	3.5(at 25℃)
form	Liquid
Specific Gravity	1.156
color	Clear yellow to brown
Water Solubility	insoluble
BRN	1305471
InChIKey	QZVQQUVWFIZUBQ-UHFFFAOYSA-N
CAS DataBase Reference	372-19-0(CAS DataBase Reference)
NIST Chemistry Reference	Benzenamine, 3-fluoro-(372-19-0)

Safety Information

Hazard Codes	Xn,T,Xi
Risk Statements	22-37/38-41-36/38-33-23/24/25
Safety Statements	26-36/39-37/39-45-36/37-28
RIDADR	UN 2941 6.1/PG 3
WGK Germany	3
RTECS	BY1400000
Hazard Note	Toxic/Irritant
HazardClass	6.1
PackingGroup	III
HS Code	29214210

MSDS Information

Provider	Language
1-Amino-3-fluorobenzene	English
ACROS	English
SigmaAldrich	English
ALFA	English

3-Fluoroaniline Usage And Synthesis

Chemical Properties	CLEAR YELLOW TO BROWN LIQUID
Uses	3-Fluoroaniline is used in the preparation of acetic acid-(3-fluoro-anilide by reacting with acetic acid anhydride. Further, it serves as a reagent in the preparation of radamide analogs as Grp94 inhibitors, which has potential to be antitumor agents.
Definition	ChEBI: A derivative of aniline in which the hydrogen at position 3 has been substituted by fluorine. It is used as a pharmaceutical intermediate.

3-Fluoroaniline Preparation Products And Raw materials

Raw materials

Iron-->Fluoroboric acid-->3-Nitroaniline

Preparation Products

4'-BROMO-3'-FLUOROACETANILIDE-->7-Quinolinecarboxylic acid-->1-(3-FLUOROPHENYL)PIPERAZINE-->3-FLUOROBENZENESULFONYL CHLORIDE-->3-Fluoroacetanilide-->3-Fluorophenol-->3-FLUORO-N-METHYLANILINE-->3-FLUOROPHENYL ISOCYANATE-->2-Bromo-5-fluoroaniline-->Torezolid-->2-Bromo-3-fluoroaniline-->(S)-N-[3-(3-FLUORO-4-IODO-PHENYL)-2-OXO-OXAZOLIDIN-5-YLMETHYL]-ACETAMIDE-->1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid-->3-Fluoro-4-nitroaniline-->3-Fluoro-2-methylaniline-->3-FLUOROTHIOANISOLE

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