Other grades of this product :
| 2-Cyanobenzyl bromide Basic information |
| Product Name: | 2-Cyanobenzyl bromide | | Synonyms: | Adjacent cyano benzyl broMide;O-CYANOBENZYL BROMIDE;ALPHA-BROMO-O-TOLUNITRILE;ALPHA-BROMO-O-TOLUONITRILE;AKOS 92624;AKOS BBS-00000052;A-BROMO-O-TOLUNITRILE;alpha-bromo-ortho-tolunitrile | | CAS: | 22115-41-9 | | MF: | C8H6BrN | | MW: | 196.04 | | EINECS: | 628-473-4 | | Product Categories: | cyanide| alkyl bromide | | Mol File: | 22115-41-9.mol |
| 2-Cyanobenzyl bromide Chemical Properties |
| Melting point | 72-74 °C(lit.) | | Boiling point | 111 °C / 1.5mmHg | | density | 1.5466 (rough estimate) | | refractive index | 1.6550 (estimate) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | Water Solubility | Slightly soluble in water | | form | Crystalline Powder or Chunks | | color | White to gray-brown | | BRN | 742605 | | InChIKey | QGXNHCXKWFNKCG-UHFFFAOYSA-N | | CAS DataBase Reference | 22115-41-9(CAS DataBase Reference) |
| Hazard Codes | C | | Risk Statements | 34 | | Safety Statements | 26-36/37/39-45-28A | | RIDADR | UN 3261 8/PG 2 | | WGK Germany | 3 | | F | 10-19-21 | | Hazard Note | Corrosive | | HazardClass | 8 | | PackingGroup | II | | HS Code | 29269090 |
| 2-Cyanobenzyl bromide Usage And Synthesis |
| Description | 2-(Bromomethyl)benzonitrile reacts with 2H-tetrazole in the presence of KOH to yield 4-[(2H-tetra-zol-2-yl)meth-yl]benzonitrile. It undergoes base-promoted condensation reaction with homophthalic anhydride to yield 6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-one. | | Chemical Properties | White to light yellow crystal powder | | Uses | 2-(Bromomethyl)benzonitrile is an intermediate in the synthesis of Alogliptin, an oral antihyperglycemic agent that is a selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4). Antidiabetic agent. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package. | | General Description | 2-(Bromomethyl)benzonitrile reacts with 2H-tetrazole in the presence of KOH to yield 4-[(2H-tetra-zol-2-yl)meth-yl]benzonitrile. It undergoes base-promoted condensation reaction with homophthalic anhydride to yield 6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-one. | | Purification Methods | Purify the nitrile by steam distillation. Extract the distillate with Et2O, dry the extract (Na2SO4), evaporate and distil the residue. The solidified distillate can be recrystallised from pet ether or cyclohexane. NMR (CDCl3) : 7.8-7.2 (m 4H), 4.62 (s, 2H), IR max 2238 cm1 . [Drory Chem Ber 24 2570 1891, Borsche et al. Chem Ber 74 685 1934, Buckley et al. Aust J Chem 22 594 1969, Beilstein 9 III 2312.] LACHRYMATORY. |
| 2-Cyanobenzyl bromide Preparation Products And Raw materials |
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