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| O-Phospho-L-serine Basic information |
| O-Phospho-L-serine Chemical Properties |
| Melting point | 190 °C(lit.) | | alpha | [α]D20 +14～+18°(c=5,dil.HCl) | | Boiling point | 475.4±55.0 °C(Predicted) | | density | 1.809±0.06 g/cm3(Predicted) | | vapor pressure | 0Pa at 20℃ | | storage temp. | under inert gas | | solubility | H2O: 50 mg/mL hot, clear, colorless to slightly yellow | | form | Crystalline Powder | | pka | pK1:2.08;pK2:5.65;pK3:9.74 (25°C) | | color | White | | Water Solubility | 28.34g/L at 20℃ | | Merck | 14,7363 | | BRN | 1726826 | | InChIKey | BZQFBWGGLXLEPQ-UWTATZPHSA-N | | CAS DataBase Reference | 407-41-0(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 21/22 | | Safety Statements | 36/37 | | RIDADR | UN 3261 8 / PGII | | WGK Germany | 3 | | F | 10 | | HS Code | 29225090 |
| O-Phospho-L-serine Usage And Synthesis |
| Description | O-Phospho-L-Serine is an agonist of the group III metabotropic glutamate receptors mGluR4a and mGluR6 (EC50s = 2-5 μM). It mimics the phosphatidylserine head group and has been shown to inhibit the proliferation of microglia and to enhance neuronal differentiation of progenitor cells. | | Chemical Properties | White powder | | Uses | roborant | | Uses | L-O-Phosphoserine is the catalytic domain of human protein kinase C β II when complexed with a malemide inhibitor. It is also used in the purification of the Epstein-Barr virus nuclear antigen 2A. | | Uses | O-Phospho-L-Serine is an agonist of the group III metabotropic glutamate receptors mGluR4a and mGluR6 (EC50s = 2-5 μM). It mimics the phosphatidylserine head group and has been shown to inhibit the proliferation of microglia and to enhance neuronal differentiation of progenitor cells. | | General Description | Monoclonal Anti-Phosphoserine (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. | | Flammability and Explosibility | Notclassified | | Biological Activity | Group III metabotropic glutamate receptor agonist; analog of L-AP4 (L-(+)-2-Amino-4-phosphonobutyric acid ). Inhibits proliferation and enhances neuronal differentiation in progenitor cells. | | Biochem/physiol Actions | Protein phosphorylation and dephosphorylation are basic signaling mechanisms that modify protein function in eukaryotic cells. Phosphorylation is a rare posttranslational event in normal tissues, however, the abundance of phosphorylated cellular proteins increases several folds following various activation processes. The main amino acids that are phosphorylated are tyrosine, serine, or threonine (pTyr/pSer/pThr), each having specific kinases that phosphorylate them and specific phosphatases that dephosphorylate them. Mono and polyclonal antibodies directed against phosphorylated residues were generated and found useful as analytical and preparative tools by enabling the identification, quantification, and immunoaffinity isolation of phosphorylated cellular proteins. | | Purification Methods | Recrystallise the phospho-serine by dissolving 10g in H2O (150mL) at 25o, stirring for up to 20minutes. Undissolved material is filtered off (Büchner), and 95% EtOH (85mL) is added dropwise during 4minutes, and set aside at 25o for 3hours, then at 3o overnight. The crystals are washed with 95% EtOH (100mL), then dry Et2O (50mL), and dried in a vacuum (yield 6.5g). A further quantity (1.5g) can be obtained by keeping the mother liquors and washings at -10o for 1 week. The DL-isomer has m 167-170o(dec) after recrystallisation from H2O/EtOH or MeOH. [Neuhaus & Korkes Biochemical Preparations 6 75 1958, Neuhaus & Byrne J Biol Chem 234 113 1959, IR: F.lsch & Mellander Acta Chem Scand 11 1232 1957, Beilstein 4 IV 3120.] |
| O-Phospho-L-serine Preparation Products And Raw materials |
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