L-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol bitartrate

L-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol bitartrate
  • CAS No.:69815-49-2

Important Notice

  1. This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
  2. This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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L-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol bitartrate Basic information
Product Name:L-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol bitartrate
Synonyms:(-)-(R)-NOREPINEPHRINE HYDROGEN TARTRATE MONOHYDRATE;(-)-arterenolbitartratehydrate;L-(-)-NOREPINEPHRINE (+)-BITARTRATE SALT MONOHYDRATE;L-NOREPINEPHRINE BITARTRATE, MONOHYDRATE;L-NORADRENALINE HYDROGEN L-TARTRATE MONOHYDRATE;L-(-)-NORADRENALINE (+)-BITARTRATE SALT MONOHYDRATE;L-NORADRENALINE BITARTRATE, MONOHYDRATE;L-NORADRENALINE BITARTRATE H2O
CAS:69815-49-2
MF:C12H19NO10
MW:337.28
EINECS:211-268-5
Product Categories:API;Other APIs;69815-49-2
Mol File:69815-49-2.mol
L-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol bitartrate Chemical Properties
Melting point 102-105 °C
alpha -46 º (c=0.5, HCl)
storage temp. 2-8°C
solubility H2O: 50 mg/mL, clear
CAS DataBase Reference69815-49-2(CAS DataBase Reference)
Safety Information
Hazard Codes T
Risk Statements 26/27/28
Safety Statements 45
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
F 8-10-23
MSDS Information
ProviderLanguage
SigmaAldrichEnglish
L-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol bitartrate Usage And Synthesis
Usesadrenergic agonist, antihypotensive
UsesL-(ndash)-Norepinephrine-(+)-bitartrate is a α,β-adrenoceptor (AR) agonist.
Brand nameLevophed (Hospira).
Purification MethodsRecrystallise adrenor from EtOH and store it in the dark under N2. [pKa, Lewis Brit J Pharmacol Chemother 9 488 1954, UV: Bergstr.m et al. Acta Physiol Scand 20 101 1950, Fluorescence: Bowman et al. Science NY 122 32 1955, Tullar J Am Chem Soc 70 2067 1948.] The L-tartrate salt monohydrate has m 102-104.5o, [] D -11o (c 1.6, H2O), after recrystallisation from H2O or EtOH. [Beilstein 13 III 2382.]
L-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol bitartrate Preparation Products And Raw materials

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