Product

(S)-(+)-4-Phenyl-2-oxazolidinone

CAS No.：99395-88-7

Other grades of this product :

(S)-(+)-4-Phenyl-2-oxazolidinone Basic information

Product Name:	(S)-(+)-4-Phenyl-2-oxazolidinone
Synonyms:	(4S)-4-PHENYL-1,3-OXAZOLIDIN-2-ONE;4-S-PHENYL-OXAZOLIDIN-2-ONE;(4S)-PHENYL-2-OXAZOLIDINONE;L-(+)-4-(4S)-PHENYLOXAZOLIDINONE;(S)-PH-OXAZOLIDINONE;SPOX;S-POA;(S)-(+)-4-PHENYLOXAZOLIDIN-2-ONE
CAS:	99395-88-7
MF:	C9H9NO2
MW:	163.17
EINECS:	619-429-5
Product Categories:	Asymmetric Synthesis;Chiral Auxiliaries;Glycidyl Compounds, etc. (Chiral);Synthetic Organic Chemistry;Chiral chemicals;Oxazolidinone Derivatives;Oxazolidinone;Chiral Compounds;chiral;Chiral Reagent;Asymmetric Synthesis;Chiral Building Blocks;Peptide;99395-88-7
Mol File:	99395-88-7.mol

(S)-(+)-4-Phenyl-2-oxazolidinone Chemical Properties

Melting point	129-132 °C(lit.)
alpha	49.5 º (c=2, CHCl3)
Boiling point	290.25°C (rough estimate)
density	1.2021 (rough estimate)
refractive index	72 ° (C=1, AcOEt)
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	12.05±0.40(Predicted)
form	Crystalline Powder
color	White
optical activity	[α]20/D +48°, c = 2 in chloroform
BRN	131918
InChIKey	QDMNNMIOWVJVLY-MRVPVSSYSA-N
CAS DataBase Reference	99395-88-7(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi,F+
Risk Statements	12-36
Safety Statements	24/25-33-26-16-7/9
WGK Germany	3
F	3-9
HS Code	29349990

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English

(S)-(+)-4-Phenyl-2-oxazolidinone Usage And Synthesis

Chemical Properties	white to light yellow crystal powde
Uses	S)-4-Phenyl-2-oxazolidinone is an intermediate for the synthesis and development for cholesterol absorption inhibitor AZD4121.
Uses	Ezetimibe intermediate
Uses	Versatile chiral auxiliary for asymmetric synthesis which is easily recycled under mild conditions, thus enhancing its commercial potential. For a recent review, see Aldrichimica Acta .

(S)-(+)-4-Phenyl-2-oxazolidinone Preparation Products And Raw materials

Raw materials	L-Proline, 3-methyl-5-oxo-, (3S)--->(R,E)-3-(BUT-2-ENOYL)-4-PHENYLOXAZOLIDIN-2-ONE-->BOC-L-Phenylglycinol-->Ethyl cyanoglyoxylate-2-oxime-->L-Phenylglycine-->(S)-(+)-2-Phenylglycinol-->D-Plenylglycinol
Preparation Products	(R)-(-)-4-Phenyl-2-oxazolidinone-->(S)-4-PHENYL-1,3-OXAZOLIDINE-2-THIONE-->(4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone-->(R)-(-)-2-Phenylpropionic acid

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