Methoxyammonium chloride
Methoxyammonium chloride
  • CAS No.:593-56-6
Other grades of this product :
Methoxyammonium chloride Basic information
Methoxyamine hydrochloride Application
Product Name:Methoxyammonium chloride
Synonyms:Methoxyamine Hydrochloride, O-Methylhydroxylamine hydrochloride, Methoxylamine hydrochloride;Methoxylamine hydrochloride solution 25-30 wt. % in H2O;Hydroxylamine, O-methyl-, hydrochloride (1:1);O-METHYLHYDROXYAMINE HYDROCHLORIDE;O-METHYLHYDROXYLAMINE HCL;O-METHYLHYDROXYLAMINE HYDROCHLORIDE;O-METHYLHYDROXYLAMMONIUM CHLORIDE;MOX REAGENT
CAS:593-56-6
MF:CH6ClNO
MW:83.52
EINECS:209-798-7
Product Categories:Amine Salts;Amino Alcohols;Building Blocks;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;Amines and Anilines;API intermediates;Amination;Hydroxylamines;Hydroxylamines (O-Substituted);Synthetic Organic Chemistry;Oxygen Compounds;API;bc0001
Mol File:593-56-6.mol
Methoxyammonium chloride Chemical Properties
Melting point 151-154 °C(lit.)
Boiling point 105-110°C
density 1.1 g/mL at 25 °C
refractive index n20/D 1.4021
storage temp. Sealed in dry,Room Temperature
solubility alcohol: soluble(lit.)
form Crystalline Powder
color White to very faint yellow
Water Solubility SOLUBLE
Sensitive Hygroscopic
Merck 14,5989
BRN 3589723
InChIKeyXNXVOSBNFZWHBV-UHFFFAOYSA-N
CAS DataBase Reference593-56-6(CAS DataBase Reference)
EPA Substance Registry SystemO-Methylhydroxylamine hydrochloride (593-56-6)
Safety Information
Hazard Codes C,Xi,N
Risk Statements 34-36/37/38-50-43-20/21/22-37-35
Safety Statements 3-24-26-36/37/39-45-61-24/25-27
RIDADR UN 3265 8/PG 2
WGK Germany 3
RTECS NC3980000
3-10
Hazard Note Corrosive/Hygroscopic
TSCA Yes
HS Code 2928 00 90
HazardClass 8
PackingGroup III
MSDS Information
ProviderLanguage
Methoxyammonium chloride English
SigmaAldrich English
ACROS English
ALFA English
Methoxyammonium chloride Usage And Synthesis
Methoxyamine hydrochlorideMethoxyamine hydrochloride (also known as O-methylhydroxylamine hydrochloride; Methoxyamine; Methoxyamine hydrochloride (OMHA), is an important medicine, pesticide intermediates. Its major applications are as follows:
  • it can be used for color photography and film printing.
  • it is used as a reducing agent in organic synthesis industry for preparation of oximes.
  • the field of medicine: it can be used for the synthesis of second-generation cephalosporins antibiotics cefuroxime (ester), neopropene, norethindine and hydroxyurea.
  • the field of pesticides: the synthesis of new efficient, low-toxicity bactericidal metominostrobin.
  • It is mainly produced by sodium nitrite method in our country.
The similar compound of methoxyamine hydrochloride, the ethoxylamine hydrochloride is mainly used for the production of herbicides, oxycarbazone, diltiazem and other herbicides.
Application
  • Used as a methoxyamine reagent, also used in the production of the side chain of Cefuroxime and other new drugs
  • Used for pesticide synthesis.
  • Use for pharmaceuticals production
  • Used for the preparation of O-methyloxime together with aldehydes or ketones.
Chemical PropertiesWhite to very faintly yellow crystalline powder
Usesantineoplastic, hydroxymethyltransferase inhibitor
UsesMethoxylamine is a methoxime derivative used as internal standard for Prostaglandin assays by gas chromatography-mass spectrometry
UsesMethoxylamine hydrochloride is used as a reagent in the preparation of O-methyl oximes from aldehydes. It is orally bioavailable small molecule inhibitor with potential adjuvant activity. It is also used as internal standard for prostaglandin assays by gas chromatography-mass spectrometry.
General DescriptionOff-white crystals.
Air & Water ReactionsWater soluble.
Reactivity ProfileIn aqueous solution, Methoxyammonium chloride behaves as an acid. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.
Fire HazardFlash point data for Methoxyammonium chloride are not available. Methoxyammonium chloride is probably combustible.
Purification MethodsCrystallise the hydrochloride from absolute EtOH or EtOH by addition of diethyl ether. [Kovach et al. J Am Chem Soc 107 7360 1985, Beilstein 1 IV 1252.]
Methoxyammonium chloride Preparation Products And Raw materials
Preparation Products4-NITRO-PYRIDIN-3-YLAMINE-->PYRIDINE-2,3,6-TRIAMINE

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