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| 10-Deacetylbaccatin III Basic information |
| 10-Deacetylbaccatin III Chemical Properties |
| Melting point | 231-236 °C | | alpha | -44.5 º (c=1, methanol 25 ºC) | | Boiling point | 717℃ | | density | 1.2007 (rough estimate) | | refractive index | 1.5376 (estimate) | | Fp | >110°(230°F) | | storage temp. | Sealed in dry,Room Temperature | | solubility | methanol: soluble, clear, colorless (5 mg + 0.1 mL MeOH) | | pka | 11.50±0.70(Predicted) | | form | Powder | | color | white | | Water Solubility | INSOLUBLE | | InChIKey | YWLXLRUDGLRYDR-IYNRKYTHSA-N | | CAS DataBase Reference | 32981-86-5(CAS DataBase Reference) |
| 10-Deacetylbaccatin III Usage And Synthesis |
| Chemical Properties | 10-Deacetylbaccatin III is White Solid
| | Uses | 10-DAB (10-Deacetylbaccatin) is an antineoplastic agent and an anti-cancer intermediate. 10-DAB (10-Deacetylbaccatin) has gained great attention because of its partly excellent anti-cancer properties. 10-DAB (10-Deacetylbaccatin) can be gained from the le | | Uses | 10-Deacetyl Baccatin III is an impurity of Paclitaxel (P132500) and derivatives. | | Uses | 10-Deacetylbaccatin III is a intermediate in the synthesis of Taxol and derivatives
| | Biological Activity | 10-dab (also known as 10-deacetylbaccatin) is an intermediate used for the preparation of taxol, an anti-leukemic and tumor-inhibiting agent isolated from the inner bark of the pacific yew tree taxus brevifolia as well as other species of the genus taxus. due to the low availability of taxol from its natural sources, 10-dab is used as a raw material for the preparation of taxol and its derivatives. being easily extracted from the annual cute of the yew leaves, 10-dab has a very folded chemical structure with the α hydroxyl group hindered at c-13 easily to form a hydrogen bond with the 4α acetyl group.f. gueritte-voegelein, v. senilh, b. david, d. guenard and p. potier. chemical studies of 10-deacetyl baccatin iii hemisynthesis of taxol derivatives. tetrahedron 1986; 42(16): 4451-4460 |
| 10-Deacetylbaccatin III Preparation Products And Raw materials |
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