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| Deoxycorticosterone acetate Basic information |
| Product Name: | Deoxycorticosterone acetate | | Synonyms: | 21-HYDROXYPROGESTERONE 21-ACETATE VETRAN;11-Deoxycorticosterone acetate, 21-Acetoxy-4-pregnene-3,20-dione, 21-Acetoxyprogesterone, 21-Hydroxy-4-pregnene-3,20-dione 21-acetate, 21-Hydroxyprogesterone 21-acetate, 4-Pregnen-21-ol-3,20-dione 21-acetate, Cortexone acetate, DOC acetate;21-Acetoxypregn-4-en-3,20-dione;21-Hydroxypregn-4-ene-3,20-dione Acetate;Decorten;Decosteron;DEOXYCORTICOSTERONE ACETATE(RG);Desoxycorticosterone Acetate (200 mg) | | CAS: | 56-47-3 | | MF: | C23H32O4 | | MW: | 372.5 | | EINECS: | 200-275-9 | | Product Categories: | PERCOTEN;Hormone Drugs;Biochemistry;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors;Hydroxyketosteroids;Steroids | | Mol File: | 56-47-3.mol |
| Deoxycorticosterone acetate Chemical Properties |
| Melting point | 157°C | | alpha | D20 +168 to +176° (dioxane) | | Boiling point | 421.94°C (rough estimate) | | density | 1.0415 (rough estimate) | | refractive index | 175 ° (C=1, Dioxane) | | storage temp. | Sealed in dry,Room Temperature | | solubility | H2O: insoluble | | form | neat | | color | White to Off-White | | Water Solubility | 4mg/L(25 ºC) | | Merck | 2901 | | BRN | 2570798 | | CAS DataBase Reference | 56-47-3(CAS DataBase Reference) |
| Safety Statements | 22-24/25 | | RIDADR | UN 2811 | | WGK Germany | 3 | | RTECS | HG0525000 | | HazardClass | IRRITANT | | HS Code | 2937290000 |
| Deoxycorticosterone acetate Usage And Synthesis |
| Chemical Properties | Off-White Solid | | Uses | Adrenocortical/mineralocorticoid Steroid. | | Uses | Deoxycorticosterone acetate has been used to induce hypertensive pregnancy. It has also been used to investigate the effect of low epicatechin dosing on the cardiovascular function of deoxycorticosterone acetate (DOCA)-salt hypertensive rats. | | Brand name | Doca (Organon); Percorten (Novartis) [Name previously used: Deoxycortone.]. | | General Description | Deoxycorticosterone acetate is an endogenous neurosteroid found in brain and peripheral circulation, which is produced by progesterone. It is both a mineralocorticoid and a glucocorticoid. It is used to treat adrenocortical insufficiency or Addison′s disease. Deoxycorticosterone acetate improves insulin sensitivity. It acts as a precursor to glucocorticoid corticosterone and the GABAergic neuroactive steroid (3α,5α)-3,21-dihydroxypregnan-20-one. | | Purification Methods | 11-Deoxycorticosterone acetate recrystallises from EtOH as needles or Me2CO/hexane, and sublimes at high vacuum. It is partly soluble in MeOH, Me2CO, Et2O and dioxane but insoluble in H2O. [Reichstein & Euw Helv Chim Acta 23 136 1940, Romo et al. J Am Chem Soc 79 5034 1957; NMR: Shoolery & Rogers J Am Chem Soc 80 5121 1959, Beilstein 8 IV 2195.] |
| Deoxycorticosterone acetate Preparation Products And Raw materials |
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