Other grades of this product :
| Isoxazole Chemical Properties |
| Melting point | -67.1°C | | Boiling point | 93-95 °C(lit.) | | density | 1.078 g/mL at 25 °C(lit.) | | vapor density | 2.4 (vs air) | | refractive index | n20/D 1.427(lit.) | | Fp | 48 °F | | storage temp. | 2-8°C | | solubility | 167g/l | | pka | -2.0(at 25℃) | | form | clear liquid | | color | Colorless to Light yellow | | BRN | 103773 | | InChIKey | CTAPFRYPJLPFDF-UHFFFAOYSA-N | | CAS DataBase Reference | 288-14-2(CAS DataBase Reference) | | NIST Chemistry Reference | Isoxazole(288-14-2) | | EPA Substance Registry System | Isoxazole (288-14-2) |
| Hazard Codes | F,Xi | | Risk Statements | 11 | | Safety Statements | 16-23/33-33-29-7/9 | | RIDADR | UN 1993 3/PG 2 | | WGK Germany | 3 | | F | 10 | | Hazard Note | Highly Flammable | | TSCA | Yes | | HazardClass | 3 | | PackingGroup | II | | HS Code | 29349990 |
| Isoxazole Usage And Synthesis |
| Description | As an important class of heterocycles, isoxazole is a five membered heterocyclic compound with various pharmacological actions, which is found in some natural products, such as ibotenic acid. It is used in the formation of the basis for a number of drugs, such as the COX-2 inhibitor valdecoxib and anti-inflammatory drugs. Isoxazoles are largely applied in the area of pharmaceuticals and therapeutics, including insecticidal, antibacterial, antibiotic, antitumour, antifungal, antituberculosis, anticancer and ulcerogenic. Besides, it has a great effect on reducing blood glucose, eliminating pain, resisting inflammation, killing harmful bacteria, controlling and reducing the risk of HIV.
The isoxazole ring is an essential pharmacophore in modern drug discovery. Some beta-lactamase-resistant antibiotics contain an isoxazole group, including cloxacillin, dicloxacillin, flucloxacillin, and the isoxazole group is also found in some steroid drug such as danazol.
| | References | https://en.wikipedia.org/wiki/Isoxazole
http://www.ijpcbs.com/files/volume3-2-2013/15.pdf
| | Chemical Properties | Colorless liquid | | Uses | Natural insecticide. | | Definition | ChEBI: A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles. | | General Description | Isoxazole are described as inhibitors of acetylcholinesterase (AChE). Isoxazole ligands bind to and inhibit the Sxc- antiporter. | | Hazard | Narcotic and psychomimetic effects. |
| Isoxazole Preparation Products And Raw materials |
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