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| GANGLIOSIDE GM1, AMMONIUM SALT, BOVINE Basic information |
| Product Name: | GANGLIOSIDE GM1, AMMONIUM SALT, BOVINE | | Synonyms: | Sodium Monosialotetrahexosylganglioside Injection;Monosialoganglioside GM1, Bovine Brain;GM1 Ganglioside (Brain, Ovine-SodiuM Salt);GM1 Ganglioside (Brain, Ovine-Sodium Salt);Monosialotetrahexosylganglioside Sodium;GM1 GANGLIOSIDE (BRAIN, OVINE-SODIUM SALT);GANGLIOSIDE GM1 (OVINE BRAIN);Ganglioside GM1 (Ovine Brain);Ganglioside GM?, Ammonium Salt, Bovine Brain | | CAS: | 37758-47-7 | | MF: | C73H134N4O31 | | MW: | 1563.85 | | EINECS: | 200-081-4 | | Product Categories: | | Mol File: | 37758-47-7.mol |
| GANGLIOSIDE GM1, AMMONIUM SALT, BOVINE Chemical Properties |
| Melting point | >182°C (dec.) | | storage temp. | −20°C | | solubility | chloroform/methanol (9:1): 10 mg/mL, clear, colorless | | form | lyophilized powder | | color | Off-White | | Merck | 14,4364 | | InChIKey | GTTLZSUWCRJZRC-CRQBLQEMSA-N |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | FK1200000 | | F | 10-21 | | HS Code | 29400090 |
| GANGLIOSIDE GM1, AMMONIUM SALT, BOVINE Usage And Synthesis |
| Chemical Properties | Off-white powder | | Uses | Ganglioside GM1 (Ovine Brain) has been used in the preparation of small unilamellar vesicles for fluorescence studies. It has also been used in liposome preparation for circular dichroism studies with human wild type?synuclein. It may be used as a standard lipid for electrospray ionization (ESI) mass spectrometry (MS) analysis. | | Definition | ChEBI: A sialotetraosylceramide consisting of a branched pentasaccharide made up from one sialyl residue, two galactose residues, one N-acetylgalactosamine residue and a glucose residue at the reducing end attached to N-stear
ylsphingosine via a beta-linkage. | | General Description | Ganglioside GM1 is referred as brain ganglioside. It is an acidic glycosphingolipid comprising N-acetylneuraminic acid or N-glycolylneuraminic acid residues. It is upregulated in developing brain. Ganglioside GM1 has five glycosyl units. | | Biochem/physiol Actions | Ganglioside GM1 is a modulator of Ca2+ flux in plasmamembrane. It plays a key role in neuronal development and maturation and has neuroprotective functionality. GM1 ganglioside from ovine has many pharmaceutical applications and is regarded as an effective therapeutic for Huntington′s disease. Accumulation of GM1 in brain due to β-galactosidase enzyme deficiency is implicated in metabolic disorder, GM1 gangliosidosis. |
| GANGLIOSIDE GM1, AMMONIUM SALT, BOVINE Preparation Products And Raw materials |
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