Product

2'-Deoxyuridine 5'-monophosphate disodium salt

CAS No.：42155-08-8

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2'-Deoxyuridine 5'-monophosphate disodium salt Basic information

Product Name:	2'-Deoxyuridine 5'-monophosphate disodium salt
Synonyms:	dump;2''-Deoxyuridine-5''-monophosphoric acid disodium salt;2'-deoxyuridine 5'-monophosphate*disodium sigma G;5'-Uridylic acid, 2'-deoxy-, disodium salt;2'-Deoxyuridine-5'-monophosphate,sodiumsalt;2'-DEOXYURIDINE 5'-MONOPHOSPHATEDISODIUM SIGMA GRA;2''-DEOXYURIDINE 5''-MONOPHOSPHATE DISODIUM SALT (DUMP-NA2);2'-Deoxy-5'-uridylic acid disodium salt
CAS:	42155-08-8
MF:	C9H11N2Na2O8P
MW:	352.15
EINECS:	255-687-1
Product Categories:
Mol File:	42155-08-8.mol

2'-Deoxyuridine 5'-monophosphate disodium salt Chemical Properties

storage temp.	-20°C
form	Powder
color	White to Off-white
Water Solubility	Soluble in water.
CAS DataBase Reference	42155-08-8(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	22-36/37/38-20/21/22
Safety Statements	26-36-37/39
WGK Germany	3
HS Code	29349990

MSDS Information

Provider	Language
SigmaAldrich	English

2'-Deoxyuridine 5'-monophosphate disodium salt Usage And Synthesis

Description	2'-Deoxyuridine 5'-monophosphate disodium salt is a nucleoside analog that inhibits the synthesis of DNA and RNA by inhibiting the enzyme thymidylate synthase, which prevents the formation of dTMP from deoxyuridine 5'-triphosphate. 2'-Deoxyuridine 5'-monophosphate disodium salt has been shown to be effective in treating squamous cell cancer and hyperproliferative diseases such as chronic myelogenous leukemia. 2'-Deoxyuridine 5'-monophosphate disodium salt is also used as an antiviral agent against HIV, herpes simplex virus, and varicella zoster virus.
Uses	2?-Deoxyuridine 5?-monophosphate (dUMP) is used by the enzyme thymidylate synthetase (TS) (EC 2.1.1.45) for the de novo production of dTMP. dUMP is used as the reference substrate in studies of dUMP analogues in potential chemotherapy applications.
General Description	2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP).
Biochem/physiol Actions	2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) conversion to pyrimidine is inhibited by methotrexate. The inhibition of dUMP to deoxythymidine monophosphate (dTMP) at the methylation step is a key in controlling bacterial and eukaryotic cell growth.

2'-Deoxyuridine 5'-monophosphate disodium salt Preparation Products And Raw materials

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