Methyl 3-(4-methoxyphenyl)oxirane-2-carboxylate

CAS No.：42245-42-1

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Methyl 3-(4-methoxyphenyl)oxirane-2-carboxylate Basic information

Product Name:	Methyl 3-(4-methoxyphenyl)oxirane-2-carboxylate
Synonyms:	METHYL TRANS-3-(4-METHOXYPHENYL)GLYCIDATE;3-(4-methoxyphenyl)-oxiranecarboxylicacimethylester;3-(-methoxyphenyl)glycidicacidmethylester;methyl 3-(p-methoxyphenyl)oxirane-2-carboxylate;Oxiranecarboxylic acid, 3-(4-methoxyphenyl)-, methyl ester;TRANS-2,3-EPOXY-3(4-METHOXYPHENYL)-PROPIONICACIDMETHYLES.;METHYL 3-(4-METHOXYPHENYL)OXIRANE-2-CARBOXYLATE;3-(4-Methoxyphenyl)-oxiranecarboxylic acid methyl ester
CAS:	42245-42-1
MF:	C11H12O4
MW:	208.21
EINECS:	255-735-1
Product Categories:	API intermediates;Epoxide Monomers;Monomers;Polymer Science
Mol File:	42245-42-1.mol

Methyl 3-(4-methoxyphenyl)oxirane-2-carboxylate Chemical Properties

Melting point	69-71 °C(lit.)
solubility	Dichloromethane; Chloroform; Ethyl Acetate; DMSO;
form	Solid
color	White
EPA Substance Registry System	Oxiranecarboxylic acid, 3-(4-methoxyphenyl)-, methyl ester (42245-42-1)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-37/39
WGK Germany	3

MSDS Information

Provider	Language
SigmaAldrich	English

Methyl 3-(4-methoxyphenyl)oxirane-2-carboxylate Usage And Synthesis

Description	Methyl 2,3 epoXY-3-(4-methoxyphenyl)propionate is an intermediate product in the synthesis of diltiazem hydrochloride. Contact dermatitis was observed in several laboratory technicians.
Uses	Methyl trans-3-(4-Methoxyphenyl)glycidate is an intermediate used in the synthesis of Clentiazem (C573035), which is a benzothiazepine-like calcium antagonists; Enhances endothelium-dependent coronary artery relaxation.
Contact allergens	Methyl 2,3 epoxy-3-(4-methoxyphenyl)propionate is an intermediate product in the synthesis of diltiazem hydrochloride. Contact dermatitis was observed in several laboratory technicians.

Methyl 3-(4-methoxyphenyl)oxirane-2-carboxylate Preparation Products And Raw materials

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