Product

(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile

CAS No.：207557-35-5

Other grades of this product :

(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile Basic information

Product Name:	(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile
Synonyms:	(2S)-1-(2-Chloroacetyl)-2-9-pyrrolidinecarbonitrile;Vildagliptin interMediate C;vildagliptin Impurity J;cas:207557-35-5;2-Pyrrolidinecarbonitrile, 1-(chloroacetyl)-, (2S)-;(S)-1-(2-CHLOROACETYL)PYRROLIDINE-2-CARBONITRILE;(2S)-1-(CHLOROACETYL)-2-PYRROLIDINECARBONITRILE;(2S)-1-CHLOROACETYLPYRROLIDINE-2-CARBONITRILE
CAS:	207557-35-5
MF:	C7H9ClN2O
MW:	172.61
EINECS:	807-388-8
Product Categories:	intermediate;ACETYLHALIDE;Pharmaceuticalintermediates
Mol File:	207557-35-5.mol

(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile Chemical Properties

Melting point	52-53 °C
Boiling point	363.1±37.0 °C(Predicted)
density	1.27±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	-4.65±0.40(Predicted)
color	Pale Yellow to Light Brown
Stability:	Hygroscopic

Safety Information

HS Code

2933998090

MSDS Information

(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile Usage And Synthesis

Chemical Properties	White crystals
Uses	(2S)-1-(2-Chloroacetyl)-2-9-pyrrolidinecarbonitrile is a key intermediate for dipeptidyl peptidase IV inhibitor Vildagliptin (V305000).

(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile Preparation Products And Raw materials

Raw materials

(S)-PYRROLIDINE-2-CARBONITRILE-->CHLOROAC-PRO-OH-->L-Prolinamide hydrochloride-->(S)-1-(2-Chloroacetyl)pyrrolidine-2-carboxaMide-->(2S)-Pyrrolidine-2-carbonitrile p-toluene sulfonate-->(S)-1-Boc-2-cyanopyrrolidine

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