1,1,1-Trifluoroacetone
1,1,1-Trifluoroacetone
  • CAS No.:421-50-1
Other grades of this product :
1,1,1-Trifluoroacetone Basic information
Product Name:1,1,1-Trifluoroacetone
Synonyms:TRIFLUOROACETONE;1,1,1-trifluoro-2-propanon;3,3,3-Trifluoroacetone;CH3COCF3;Methyl trifluoromethyl ketone;Trifluoromethyl methyl ketone;1,1,1-TRIFLUOROACETONE;1,1,1-TRIFLUORO-2-PROPANONE
CAS:421-50-1
MF:C3H3F3O
MW:112.05
EINECS:207-005-9
Product Categories:C3 to C6;Carbonyl Compounds;Ketones
Mol File:421-50-1.mol
1,1,1-Trifluoroacetone Chemical Properties
Melting point -78 °C
Boiling point 22 °C(lit.)
density 1.252 g/mL at 25 °C(lit.)
vapor pressure 13.62 psi ( 20 °C)
refractive index n20/D 1.3(lit.)
Fp −23 °F
storage temp. 2-8°C
solubility Chloroform, Methanol
form Liquid
color Clear colorless
Water Solubility Miscible
Sensitive Lachrymatory
BRN 1748614
Stability:Volatile
InChIKeyFHUDAMLDXFJHJE-UHFFFAOYSA-N
CAS DataBase Reference421-50-1(CAS DataBase Reference)
NIST Chemistry Reference2-Propanone, 1,1,1-trifluoro-(421-50-1)
EPA Substance Registry System2-Propanone, 1,1,1-trifluoro- (421-50-1)
Safety Information
Hazard Codes F+,Xi,F
Risk Statements 12-36/37/38
Safety Statements 16-26-29-33-36-7/9-9-37/39-39
RIDADR UN 1993 3/PG 1
WGK Germany 3
19
Hazard Note Flammable/Lachrymatory
TSCA T
HazardClass 3
PackingGroup I
HS Code 29147090
MSDS Information
ProviderLanguage
1,1,1-Trifluoro-2-propanone English
SigmaAldrich English
ACROS English
ALFA English
1,1,1-Trifluoroacetone Usage And Synthesis
Chemical Properties1,1,1-Trifluoroacetone is CLEAR COLOURLESS LIQUID
Uses1,1,1-Trifluoroacetone is used as intermediate of bioactive substance and antihypertensive drug, and as effective synthetic building block and trifluoromethyl reaction reagent.
Uses1,1,1-Trifluoroacetone is a general chemical reagent used in the synthesis of glucokinase-glucokinase regulatory protein) GK-GKRP disruptors which may act as potential targets for type II diabetics. Reactant for enantioselective cycloadditions.
UsesUsed in a synthesis of 2-trifluoromethyl-7-azaindoles starting with 2,6-dihalopyridines. The derived chiral imine was used to prepare enantiopure α-trifluoromethyl alanines and diamines via a Strecker reaction followed by either nitrile hydrolysis or reduction.

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