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| Pilocarpine nitrate Basic information |
| Pilocarpine nitrate Chemical Properties |
| Melting point | 173,5-174°C | | alpha | D +77 to +83° (c = 10) | | refractive index | 81 ° (C=2, H2O) | | storage temp. | 2-8°C | | solubility | H2O: 0.1 g/mL, clear, very faintly yellow | | form | powder | | color | white | | optical activity | [α]25/D +83°, c = 10 in H2O(lit.) | | Merck | 14,7424 | | BRN | 4171406 | | CAS DataBase Reference | 148-72-1(CAS DataBase Reference) | | EPA Substance Registry System | Pilocarpine nitrate (148-72-1) |
| Hazard Codes | Xn,T+ | | Risk Statements | 22-26/28 | | Safety Statements | 1-25-45 | | RIDADR | 3087 | | WGK Germany | 3 | | RTECS | TK1455000 | | F | 3-10 | | HazardClass | 6.1(b) | | PackingGroup | III | | HS Code | 2939800000 | | Toxicity | LD50 oral in rat: 911mg/kg |
| Pilocarpine nitrate Usage And Synthesis |
| Chemical Properties | White or almost white, crystalline powder or colourless crystals, sensitive to light. | | Uses | antiglaucoma agent, miotic | | Uses | Antiglaucoma drug;Cholinergic | | Uses | Pilocarpine nitrate salt has been used to measure bronchoconstriction and M2 and M3 muscarinic receptor function in vivo. It has also been used to induce electrographic and behavioral seizures and to study the different patterns of neuronal activation and neurodegeneration in Proechimys rats and Wistar rats. | | Brand name | Pilagan (Allergan). | | General Description | Pilocarpine mononitrate occursas shining white crystals that are not hygroscopic butare light sensitive. It is soluble in water (1:4) and alcohol(1:75) but insoluble in chloroform and ether. Aqueoussolutions are slightly acid to litmus and may be sterilizedin the autoclave. The alkaloid is incompatible with alkalies,iodides, silver nitrate, and reagents that precipitatealkaloids. | | Biochem/physiol Actions | Pilocarpine is a cholinergic muscarinic agonist, useful in inducing epilepsy in animal models. It is specially used to study the pathogenesis of epileptogenesis and pharmacoresistant epilepsy. Pilocarpine application is more popular among the rat and mice models. |
| Pilocarpine nitrate Preparation Products And Raw materials |
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