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| Artemether Basic information |
| Product Name: | Artemether | | Synonyms: | methyl-dihydroartemisinine;[3r-(3r,5as,6s,8as,9r,10r,12s,12ar**)]-decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12h-pyrano[4,3-j]-1,2-benzodioxepin;ARTEMETHER;ARTHEMETER;Artimether;ArtemetherC16H26O5;cgp56696;dihydroartemisininmethylether | | CAS: | 71963-77-4 | | MF: | C16H26O5 | | MW: | 298.37 | | EINECS: | 663-549-0 | | Product Categories: | Chiral Reagents;Heterocycles;Antimalarial;Intermediates & Fine Chemicals;Pharmaceuticals;chemical reagent;Herb extract;Inhibitor;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;PALUTHER;natural product;API;71963-77-4 | | Mol File: | 71963-77-4.mol |
| Artemether Chemical Properties |
| Melting point | 86-88°C | | Boiling point | 359.79°C (rough estimate) | | alpha | D19.5 +171° (c = 2.59 in CHCl3) | | density | 1.0733 (rough estimate) | | refractive index | 1.6200 (estimate) | | storage temp. | room temp | | solubility | DMSO: ≥20mg/mL | | form | powder | | color | off-white to light brown | | optical activity | [α]/D +155 to +175°, c = 0.5 in methanol | | Merck | 14,815 |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 24/25 | | WGK Germany | 3 | | RTECS | KD4165000 | | HS Code | 29329930 | | Hazardous Substances Data | 71963-77-4(Hazardous Substances Data) | | Toxicity | LD50 i.m. in mice: 263 mg/kg (China Cooperative Research Group on Qinghaosu) |
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[3R-(3R,5aS,6S,8aS,9R,10R,12S,12aR**)]-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin
| English |
| Artemether Usage And Synthesis |
| Description | Artemether is an antiparasitic compound and a derivative of artemisinin . It induces mortality in adult wild-type and pfatp6-mutant P. falciparum but the efficacy is decreased in the mutants (IC50s = 8.2 and 13.5 nM, respectively). Artemether reduces parasitemia in P. falciparum-infected monkeys and P. berghei-infected mice with 50% curative dose (CD50) values of 7.1 and 55 mg/kg, respectively. It also reduces the worm burden of S. mansoni trematodes in mice when used at doses ranging from 200 to 500 mg/kg. Formulations containing artemether have been used in the treatment of malaria. | | Chemical Properties | White Solid | | Uses | Derivative of Artemisinin (A777500). Antimalarial, used to treat strains of malaria which are multi-drug resistant. | | Uses | atypical antidepressant, norepinephrine and dopamine reuptake inhibitor, and nicotinic antagonist | | Uses | Artemether and lumefantrine combination therapy is indicated for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum, including malaria acquired in chloroquine-resistant areas. May also be used to treat uncomplicated malaria when | | Definition | ChEBI: An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falcip
rum malaria. | | General Description | Artemisinin (ART) is a natural compound present in Artemisia annua, a traditional Chinese plant. | | Biochem/physiol Actions | Artemether is a methyl ether derivative of artemisinin. It is used against multi-drug resistant strains of the malaria parasite, Plasmodium falciparum, and shows potential in treatment of schistosomiasis. | | Safety Profile | Poison by intramuscular route.Experimental reproductive effects. When heated todecomposition it emits acrid smoke and irritating fumes. |
| Artemether Preparation Products And Raw materials |
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