Other grades of this product :
| AZD7545 Basic information |
| Product Name: | AZD7545 | | Synonyms: | CS-1842;AZD-7547;AZD4575;(2,4-Dihydroxy-5-isopropylphenyl)5-[(4-methyl-1-piperazinyl)meth yl]-1,3-dihydro-2H-isoindol-2-ylmethanone, 99%;AZD 7547;AZD7547;AZD7545;AZD7545/AZD-7545;4-[[3-Chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methyl-1-oxopropyl]amino]phenyl]sulfonyl]-N,N-dimethylbenzamide | | CAS: | 252017-04-2 | | MF: | C19H18ClF3N2O5S | | MW: | 478.87 | | EINECS: | | Product Categories: | Inhibitors;API | | Mol File: | 252017-04-2.mol |
| AZD7545 Chemical Properties |
| Boiling point | 683.1±55.0 °C(Predicted) | | density | 1.473±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | ≥21.85 mg/mL in DMSO; insoluble in H2O; ≥15.63 mg/mL in EtOH with ultrasonic | | form | solid | | pka | 10.39±0.29(Predicted) |
| AZD7545 Usage And Synthesis |
| Description | AZD 7545 is an inhibitor of pyruvate dehydrogenase (PDH) kinases (PDKs), resulting in an increase in PDH activity with an EC50 value of 5.2 nM for PDK2. It less potently inhibits PDK1 and PDK3 (IC50s = 87 and 600 nM, respectively). AZD 7545 stimulates pyruvate oxidation in rat hepatocytes (EC50 = 105 nM) and significantly elevates muscle PDH activity in obese Zucker rats. It elevates postprandial glucose levels and improves the 24 hour glucose profile in obese, insulin-resistant rats, compared with lean counterparts. | | references | [1] morrell j a, orme j, butlin r j, et al. azd7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2. biochemical society transactions, 2003, 31(6): 1168-1170.[2] mayers r m, butlin r j, kilgour e, et al. azd7545, a novel inhibitor of pyruvate dehydrogenase kinase 2 (pdhk2), activates pyruvate dehydrogenase in vivo and improves blood glucose control in obese (fa/fa) zucker rats. biochemical society transactions, 2003, 31(6): 1165-1167. |
| AZD7545 Preparation Products And Raw materials |
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