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| RK-20449 trihydrochloride Basic information |
| Product Name: | RK-20449 trihydrochloride | | Synonyms: | RK 20449 trihydrochloride;RK20449 trihydrochloride;RK-20449 trihydrochloride;7-[trans-4-(4-Methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride (1:3);A-419259 (hydrochloride);A 419259 3HCl;A419259 TRIHYDROCHLORIDE;A-419259 TRIHYDROCHLORIDE;RK 20449 TRIHYDROCHLORIDE;RK20449 TRIHYDROCHLORIDE;RK-20449 TRIHYDROCHLORIDE;A419259; A-419259 TRIHYDROCHLORIDE | | CAS: | 1435934-25-0 | | MF: | C29H35ClN6O | | MW: | 519.09 | | EINECS: | | Product Categories: | API | | Mol File: | 1435934-25-0.mol |
| RK-20449 trihydrochloride Chemical Properties |
| solubility | Soluble in DMSO | | form | crystalline solid |
| RK-20449 trihydrochloride Usage And Synthesis |
| Biological Activity | a 419259 trihydrochloride is an orally available inhibitor of lck with ic50 value of 15 nm [1].lck is a src family tyrosine kinase. inhibition of this enzyme results in a prevention of t-cell activation and provides an application for treating t-cell dependent processes such as autoimmune and inflammatory diseases. a 419259 trihydrochloride is screened out by its potent inhibitory activity against the recombinant lck (64–509) with ic50 value of 15nm. it is also a selective inhibitor. it shows inactive against a panel of other kinases including cmet, igfr, pkc and pdgfr. besides that, a 419259 trihydrochloride is found to inhibit the production of il-2 with ic50 value of 25nm in jurkat cells. moreover, administration of a 419259 trihydrochloride reduces il-2 production in mice with ed50 value of 2.5 mg/kg. a 419259 trihydrochloride also has efficacy of the antigen specific t-cell immune response. administration of this compound inhibits ifn-γ production during the in vivo priming phase [1]. | | references | [1] calderwood d j, johnston d n, munschauer r, et al. pyrrolo [2, 3-d] pyrimidines containing diverse n-7 substituents as potent inhibitors of lck. bioorganic & medicinal chemistry letters, 2002, 12(12): 1683-1686. |
| RK-20449 trihydrochloride Preparation Products And Raw materials |
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