2,2,5-Trimethyl-1,3-dioxane-4,6-dione

CAS No.：3709-18-0

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
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2,2,5-Trimethyl-1,3-dioxane-4,6-dione Basic information

Product Name:	2,2,5-Trimethyl-1,3-dioxane-4,6-dione
Synonyms:	CHEMPACIFIC 41980;CYCL-ISOPROPYLIDENE METHYLMALONATE;METHYLMALONIC ACID CYCLIC ISOPROPYLIDENE ESTER;METHYL MELDRUM'S ACID;2,2,5-TRIMETHYL-1,3-DIOXANE-4,6-DIONE;1,3-DIOXANE-4,6-DIONE, 2,2,5-TRIMETHYL;2-METHYLCYCLOPROPANECARBOXYLIC ACID, 98% , MIXTURE OF CIS AND TRANS;2,2,5-Trimethyl-1,3-Dioxane-4,6-Dione 98%
CAS:	3709-18-0
MF:	C7H10O4
MW:	158.15
EINECS:	223-050-7
Product Categories:
Mol File:	3709-18-0.mol

2,2,5-Trimethyl-1,3-dioxane-4,6-dione Chemical Properties

Melting point	111-114 °C(lit.)
Boiling point	203.22°C (rough estimate)
density	1.1229 (rough estimate)
refractive index	1.4610 (estimate)
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform, Methanol
form	Solid
pka	13.14±0.40(Predicted)
color	White to Off-White
BRN	124044
InChIKey	KJMCAXYHYPDRAV-UHFFFAOYSA-N
CAS DataBase Reference	3709-18-0(CAS DataBase Reference)

Safety Information

Safety Statements	23-24/25
WGK Germany	3
F	10-21
HS Code	29171990

MSDS Information

Provider	Language
2,2,5-Trimethyl-1,3-dioxane-4,6-dione	English
ACROS	English
SigmaAldrich	English

2,2,5-Trimethyl-1,3-dioxane-4,6-dione Usage And Synthesis

Chemical Properties	White to slightly pink crystalline powder
Uses	2,2,5-Trimethyl-1,3-dioxane-4,6-dione is used as a reagent in the synthesis of 3'',4''-bis-difluoromethoxycinnamoylanthranilate (FT061) which is an orally-active antifibrotic agent that reduces albuminuria in rat models of progressive diabetic nephropathy.
Uses	2,2,5-Trimethyl-1,3-dioxane-4,6-dione was used for trapping the adduct formed during the reaction between alkyl isocyanides and dialkyl acetylenedicarboxylates.
General Description	X-ray irradiated single crystals of 2,2,5-trimethyl-1,3-dioxane-4,6-dione have been investigated by electron spin resonance (ESR), electron nuclear double resonance (ENDOR) and electron-electron double resonance (ELDOR) spectra.

2,2,5-Trimethyl-1,3-dioxane-4,6-dione Preparation Products And Raw materials

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