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| 5-Chlorothiophene-2-sulfonyl chloride Basic information |
| 5-Chlorothiophene-2-sulfonyl chloride Chemical Properties |
| Melting point | 25-28°C | | Boiling point | 112-117 °C (lit.) | | density | 1.623 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.586(lit.) | | Fp | >230 °F | | storage temp. | 2-8°C | | form | solid | | Specific Gravity | 1.623 | | color | Colorless to Yellow to Orange | | Water Solubility | Not miscible in water. | | Sensitive | Moisture Sensitive | | BRN | 130710 | | InChIKey | SORSTNOXGOXWAO-UHFFFAOYSA-N | | CAS DataBase Reference | 2766-74-7(CAS DataBase Reference) |
| Hazard Codes | C | | Risk Statements | 34-29-14 | | Safety Statements | 26-27-36/37/39-45-28A-25 | | RIDADR | UN 3265 8/PG 2 | | WGK Germany | 3 | | Hazard Note | Corrosive | | HazardClass | 8 | | PackingGroup | II | | HS Code | 29349990 |
| 5-Chlorothiophene-2-sulfonyl chloride Usage And Synthesis |
| Chemical Properties | 5-Chlorothiophene-2-sulfonyl chloride is white to yellow crystalline low melting solid
| | Uses | 5-Chloro-2-thiophenesulfonyl Chloride is a sulfonylthiophene derivative used in the preparation of Notch-1-sparing γ-secretase inhibitors for the treatment of Alzheimer's disease. | | Uses | 5-Chlorothiophene-2-sulfonyl chloride is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuffs. It is used in the preparation of Notch-1-sparing γ-secretase inhibitors for the treatment of Alzheimer's disease. | | Synthesis Reference(s) | Tetrahedron, 21, p. 1333, 1965 DOI: 10.1016/S0040-4020(01)98293-6 | | General Description | 5-Chlorothiophene-2-sulfonyl chloride can be prepared from 2-chlorothiophene by reacting with chlorosulfonic acid in the presence of phosphorus pentachloride. |
| 5-Chlorothiophene-2-sulfonyl chloride Preparation Products And Raw materials |
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