2-Chloro-5-aminophenol

CAS No.：6358-06-1

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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2-Chloro-5-aminophenol Basic information

Product Name:	2-Chloro-5-aminophenol
Synonyms:	3-amino-6-chlorophenol;5-amino-2-chloro-pheno;2-CHLORO-5-AMINOPHENOL;5-AMINO-2-CHLOROPHENOL;4-Chloro-3-hydroxyaniline;2-ch1oro-5-aminophenol;5-azanyl-2-chloro-phenol;2-Chloro-5-aminophenol, >=99%
CAS:	6358-06-1
MF:	C6H6ClNO
MW:	143.57
EINECS:
Product Categories:	Amines;blocks
Mol File:	6358-06-1.mol

2-Chloro-5-aminophenol Chemical Properties

Melting point	160 °C
Boiling point	185.5°C (rough estimate)
density	1.2028 (rough estimate)
refractive index	1.5618 (estimate)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	DMSO, Methanol
form	Powder
pka	8.55±0.10(Predicted)
color	Gray
Sensitive	Light Sensitive
InChIKey	JSCNCRWPXOTDDZ-UHFFFAOYSA-N
CAS DataBase Reference	6358-06-1(CAS DataBase Reference)
EPA Substance Registry System	Phenol, 5-amino-2-chloro- (6358-06-1)

Safety Information

Hazard Codes	Xi
Safety Statements	24/25
RTECS	SJ5720000
HazardClass	6.1
HS Code	29089990

MSDS Information

2-Chloro-5-aminophenol Usage And Synthesis

Chemical Properties	White powder
Uses	5-Amino-2-chlorophenol is used in the synthesis of antimalarial quinolones. Also used in the synthesis of potent anti-HIV agents based upon pyrimidinylphenylamine 1.

2-Chloro-5-aminophenol Preparation Products And Raw materials

Raw materials

4-Chloro-3-methoxyaniline-->2-Chloro-5-nitrophenol-->2-CHLORO-5-NITROANISOLE-->2-Methoxy-4-nitroaniline-->2-Amino-5-nitrophenol

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