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| (S)-(-)-ALPHA-METHYL-1-NAPHTHALENEMETHANOL Basic information |
| (S)-(-)-ALPHA-METHYL-1-NAPHTHALENEMETHANOL Chemical Properties |
| Melting point | 47-49 °C(lit.) | | alpha | -77 º (C=1 IN MEOH) | | Boiling point | 165°C/11mmHg(lit.) | | density | 1.113±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 14.29±0.20(Predicted) | | form | Powder | | color | Yellow | | optical activity | [α]20/D 77°, c = 1 in methanol | | BRN | 2045009 | | CAS DataBase Reference | 15914-84-8(CAS DataBase Reference) |
| (S)-(-)-ALPHA-METHYL-1-NAPHTHALENEMETHANOL Usage And Synthesis |
| Chemical Properties | White fine crystalline powder | | Uses | (S)?-?1-?(Naphthalen-?1-?yl)?ethanol is a building block used in the synthesis of novel 2,4-diaminoquinazoline derivatives as SMN2 promoter activators for the potential treatment of spinal muscular atrophy. | | Purification Methods | Purify the alcohol by recrystallisation from Et2O/pet ether, Et2O, hexane [Balfe et al. J Chem Soc 797 1946, IR, NMR: Theisen & Heathcock J Org Chem 53 2374 1988, see also Fredga et al. Acta Chem Scand 11 1609 1957]. The RS-alcohol [57605-95-5] has m 63-65o, 65-66o from hexane. [Beilstein 6 III 3034, 6 IV 4346.] |
| (S)-(-)-ALPHA-METHYL-1-NAPHTHALENEMETHANOL Preparation Products And Raw materials |
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