2-Aminopurine

CAS No.：452-06-2

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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2-Aminopurine Basic information

Product Name:	2-Aminopurine
Synonyms:	1H-PURINE-2-AMINE;2-AMINOPURINE, HYDROCHLORIDE;2-AMINOPURINE;1H-Purin-2-amine;4-purinamine;2-amino-purin;9H-Purin-2-amine;SQ 22,451
CAS:	452-06-2
MF:	C5H5N5
MW:	135.13
EINECS:	207-197-4
Product Categories:	Heterocycles;Biochemistry;Nucleobases and their analogs;Nucleosides, Nucleotides & Related Reagents;Nucleic acids;Bases & Related Reagents;PYRIMIDINE;Purine;Nucleotides and Nucleosides;Purines;Nucleotides;Nucleoside Analogs;Nucleosides, Nucleotides, Oligonucleotides;Biochemicals and Reagents
Mol File:	452-06-2.mol

2-Aminopurine Chemical Properties

Melting point	280-282 °C (lit.)
Boiling point	238.81°C (rough estimate)
density	1.3795 (rough estimate)
refractive index	1.7000 (estimate)
storage temp.	2-8°C
solubility	Aqueous Acid (Slightly), Methanol (Slightly, Heated)
form	Amorphous Powder
pka	8.02±0.20(Predicted)
color	Light beige
Stability:	Hygroscopic
InChIKey	MWBWWFOAEOYUST-UHFFFAOYSA-N
CAS DataBase Reference	452-06-2(CAS DataBase Reference)
NIST Chemistry Reference	Purine, 2-amino-(452-06-2)

Safety Information

Hazard Codes	Xn
Risk Statements	22-36/37/38-20/21/22
Safety Statements	22-36-26
WGK Germany	3
RTECS	UO7475000
HS Code	29349990
Toxicity	mmo-sat 100 mg/PLATE MUREAV 111,283,83

MSDS Information

Provider	Language
9H-Purin-2-amine	English
ACROS	English
SigmaAldrich	English

2-Aminopurine Usage And Synthesis

Chemical Properties	white to light yellow crystal powder
Uses	A probe of structural dynamics and charge transfer in DNA .
Uses	2-Aminopurine has been used to inhibit eukaryotic initiation factor-2α (eIF2α)-phosphorylation of osteoarthritis (OA) chondrocytes.
Uses	A probe of structural dynamicas and charge transfer in DNA
Definition	ChEBI: The parent compound of the 2-aminopurines, comprising a purine core carrying an amino substituent at the 2-position.
Biochem/physiol Actions	2-Aminopurine (2AP) is an analog of guanosine and adenosine, which can base pair with cytosine and thymine. It is used as a fluorescent probe in nucleic acid structure and dynamics. 2-Aminopurine (2-AP) inhibits double-stranded RNA-dependent protein kinase, protein kinase R (PKR).
Safety Profile	Mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx.

2-Aminopurine Preparation Products And Raw materials

Raw materials	Amipurimycin-->6-Chloroguanine
Preparation Products	Famciclovir-->2-(Methylthio)-9H-purine-->2-Hydroxypyrimidine

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