| 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Basic information |
| Product Name: | 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide |
| Synonyms: | 1-ETHYL-3-(3-DIMETHYLAMINOPROPYL) CARBODIIMIDE;1-(3-DIMETHYLAMINOPROPYL)-3-ETHYLCARBODIIMIDE;WATER-SOLUBLE CARBODIIMIDE;WSCD;WSCI;N-ETHYL-N'-(3-DIMETHYLAMINOPROPYL)CARBODIIMIDE;N-(3-DIMETHYLAMINOPROPYL)-N'-ETHYLCARBODIIMIDE;[3-(Dimethylamino)propyl]ethylcarbodiimide |
| CAS: | 1892-57-5 |
| MF: | C8H17N3 |
| MW: | 155.24 |
| EINECS: | 217-579-2 |
| Product Categories: | straight chain compounds |
| Mol File: | 1892-57-5.mol |
| 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Chemical Properties |
| Boiling point | 66-68°C/1mm |
| density | 0.877 g/mL at 20 °C (lit.) |
| refractive index | n |
| Fp | 66-68°C/1mm |
| storage temp. | -20°C |
| solubility | Chloroform |
| pka | 9.52±0.28(Predicted) |
| form | Liquid |
| Specific Gravity | 0.885 |
| color | Colorless to slightly yellow |
| Water Solubility | Soluble in water. |
| Sensitive | Air Sensitive |
| BRN | 507429 |
| InChIKey | LMDZBCPBFSXMTL-UHFFFAOYSA-N |
| CAS DataBase Reference | 1892-57-5(CAS DataBase Reference) |
| NIST Chemistry Reference | 1,3-Propanediamine, n'-(ethylcarbonimidoyl)-n,n-dimethyl-(1892-57-5) |
| EPA Substance Registry System | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl- (1892-57-5) |
| Safety Information |
| Hazard Codes | C |
| Risk Statements | 34 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 2735 8/PG 3 |
| WGK Germany | 3 |
| F | 1-3-10 |
| TSCA | Yes |
| HazardClass | 8 |
| PackingGroup | III |
| HS Code | 29252900 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| ALFA | English |
| 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Usage And Synthesis |
| Chemical Properties | Clear light yellow liquid |
| Uses | 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide is used as a carboxyl activating agent and activate phosphate groups in phospho mono and di esters. It is used in peptide synthesis, 3'-amino-3'-deoxyadenosine-5'-di- and triphosphates and in the preparation of antibodies like immunoconjugates. It plays a vital role for immobilization of large biomolecules in association with N-hydroxysuccinimide. It is also used in the acylation of phosphoranes. |
| General Description | N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide is commonly used in combination with N-hydroxysuccinimide (NHS) in carbodiimide coupling reaction to activate carboxyl group for coupling with amines to form amides. |
| 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Preparation Products And Raw materials |
| Raw materials | Diethyl ether-->Dichloromethane-->Potassium carbonate-->Triethylamine-->Tosyl chloride-->3-Dimethylaminopropylamine-->Ethyl isocyanate |
| Preparation Products | N-Succinimidyl Methacrylate |
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