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| Sodium deoxycholate Basic information |
| Sodium deoxycholate Chemical Properties |
| Melting point | 357-365 °C | | alpha | 44 º (c=2, H2O) | | density | 1.012 at 20.07℃ | | vapor pressure | 0Pa at 20℃ | | Fp | >110°C (own results) | | storage temp. | room temp | | solubility | water: soluble1 gm in 10 ml, clear, colorless to very faintly yellow | | form | Powder | | color | Yellow-tan | | PH | 7.5-9.0 (20g/l, H2O, 20℃) | | Odor | Odorless | | PH Range | 7 - 10 | | optical activity | [α]20/D +44±2°, c = 2% in H2O | | Water Solubility | 330 g/L (15 ºC) | | BRN | 3581950 | | LogP | 5.35 at 22℃ and pH5.7 | | Surface tension | 41.8mN/m at 1g/L and 20℃ | | CAS DataBase Reference | 302-95-4(CAS DataBase Reference) | | EPA Substance Registry System | Cholan-24-oic acid, 3,12-dihydroxy-, monosodium salt, (3.alpha.,5.beta.,12.alpha.)- (302-95-4) |
| Hazard Codes | Xn | | Risk Statements | 22-37 | | Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | FZ2250000 | | F | 3-10 | | TSCA | Yes | | HS Code | 29181930 | | Toxicity | LD50 orally in Rabbit: 1370 mg/kg |
| Sodium deoxycholate Usage And Synthesis |
| Chemical Properties | Sodium deoxycholate is white to cream crystalline powder
| | Uses | Sodium deoxycholate is used as a component in cell lysis buffers.
| | Uses | Sodium deoxycholate is an ionic detergent for the solubilization of membrane-bound proteins.
| | Uses | Sodium deoxycholate is used as a choleretic and an anionic detergent. It is useful for the extraction of membrane receptors, plasma membrane proteins, nuclei isolation and solubilizes fats as well as membrane components. It acts as an intermediate for the production of corticosteroids and microbiological diagnostic media. In addition, it acts as a catalyst in the preparation of protein extracts for immunoblotting and immunoprecipitation of radiolabeled proteins. | | General Description | Sodium deoxycholate is a bile salt and an ionic detergent. Bile salts work along with lipids/fats/cholesterol and form mixed micelles in the intestine. These micelles help in fat digestion and absorption through the intestinal wall. | | Biochem/physiol Actions | Solubilizes fats for absorption in the intestines. | | Safety Profile | Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NasO. | | Purification Methods | Recrystallise it from EtOH and dry it in an oven at 100o. The solution is freed from soluble components by repeated extraction with acid-washed charcoal. [Beilstein 10 IV 1608.] |
| Sodium deoxycholate Preparation Products And Raw materials |
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