5-(Trifluoromethyl)pyridine-2-carboxylic acid

CAS No.：80194-69-0

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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5-(Trifluoromethyl)pyridine-2-carboxylic acid Basic information

Product Name:	5-(Trifluoromethyl)pyridine-2-carboxylic acid
Synonyms:	5-(TRIFLUOROMETHYL)PICOLINIC ACID;5-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXYLIC ACID;5-TRIFLUOROMETHYL-2-PYRIDINECARBOXYLIC ACID;5-Trifluoromethyl-2-Pyridineca;5-(Trifluoromethyl)pyridine-2-carboxylic acid 97%;5-(Trifluoromethyl)pyridine-2-carboxylicacid97%;5-trifluoro-2-pyridinecarboxylic acid;5-(Trifluoromethyl)picolinic acid, 2-Carboxy-5-(trifluoromethyl)pyridine
CAS:	80194-69-0
MF:	C7H4F3NO2
MW:	191.11
EINECS:
Product Categories:	Carboxylic Acids;Pyridines;Carboxylic Acids;Fluorine series
Mol File:	80194-69-0.mol

5-(Trifluoromethyl)pyridine-2-carboxylic acid Chemical Properties

Melting point	135-137°C
Boiling point	273.7±40.0 °C(Predicted)
density	1.484±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	3.13±0.10(Predicted)
form	Powder
color	Pale brown
Water Solubility	Slightly soluble in water.
CAS DataBase Reference	80194-69-0(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26
WGK Germany	3
HazardClass	IRRITANT
HS Code	2933399990

MSDS Information

5-(Trifluoromethyl)pyridine-2-carboxylic acid Usage And Synthesis

Uses	5-(Trifluoromethyl)pyridine-2-carboxylic acid is an intermediate used in the synthesis of β-secretase (BACE) inhibitors.
Uses	5-(Trifluoromethyl)pyridine-2-carboxylic acid is an intermediate used in the synthesis of β-secretase (BACE) inhibitors.

5-(Trifluoromethyl)pyridine-2-carboxylic acid Preparation Products And Raw materials

Raw materials	Ethyl acetate-->Diethyl ether-->Tetrahydrofuran-->N,N-Dimethylformamide-->Toluene-->n-Butyllithium-->Hexane-->Nitrogen-->CARBON DIOXIDE-->Iodine-->N-Methyl-2-pyrrolidone-->(Trifluoromethyl)trimethylsilane-->2,5-Dibromopyridine-->2-Bromo-5-(trifluoromethyl)pyridine-->2-Iodo-5-trifluoromethylpyridine-->(5-TRIFLUOROMETHYL-PYRIDIN-2-YL)-ACETONITRILE
Preparation Products	5-TRIFLUOROMETHYL-PYRIDINE-2-CARBOXYLICACIDMETHYLESTER

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