3-Chloro-2-butanone

3-Chloro-2-butanone
  • CAS No.:4091-39-8

Important Notice

  1. This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
  2. This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
  3. The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.
Other grades of this product :
3-Chloro-2-butanone Basic information
Product Name:3-Chloro-2-butanone
Synonyms:3-CHLORO-2-BUTANONE;3-CHLOROBUTANONE;3-CL-MEK;2-CHLORO-3-BUTANONE;1-CHLOROETHYL METHYL KETONE;1-ACETYL-1-CHLOROETHANE;3-chloro-2-butanon;3-Chloro-2-oxobutane~Methyl alpha-chloroethyl ketone
CAS:4091-39-8
MF:C4H7ClO
MW:106.55
EINECS:223-834-9
Product Categories:C3 to C6;Carbonyl Compounds;Industrial/Fine Chemicals;ketone;API intermediates;Ketones;Organics
Mol File:4091-39-8.mol
3-Chloro-2-butanone Chemical Properties
Melting point 
Boiling point 114-117 °C (lit.)
density 1.055 g/mL at 25 °C (lit.)
refractive index n20/D 1.421(lit.)
Fp 70 °F
storage temp. Flammables area
solubility 30g/l
form clear liquid
Specific Gravity1.058 (20/4℃)
color Light orange to Yellow to Green
PH2.4 (25g/l, H2O, 20℃)
explosive limit2.3%(V)
Water Solubility 3 g/100 mL
BRN 385637
CAS DataBase Reference4091-39-8(CAS DataBase Reference)
NIST Chemistry Reference2-Butanone, 3-chloro-(4091-39-8)
EPA Substance Registry System2-Butanone, 3-chloro- (4091-39-8)
Safety Information
Hazard Codes Xn
Risk Statements 10-22-36/37/38-20/21/22-2011/10/22
Safety Statements 16-36/37/39-26-24/25
RIDADR UN 1224 3/PG 3
WGK Germany 3
RTECS EL7062000
TSCA Yes
HazardClass 3
PackingGroup III
HS Code 29147090
MSDS Information
ProviderLanguage
3-Chloro-2-butanone English
SigmaAldrich English
ACROS English
ALFA English
3-Chloro-2-butanone Usage And Synthesis
Chemical PropertiesCLEAR YELLOW TO BROWNISH LIQUID
Uses3-Chloro-2-butanone was used in production of chiral alcohols from acetophenone derivatives, β-ketoesters and N-Boc-3-pyrrolidinone by recombinant E. coli cells. It was used in the synthesis of carbene precursor, 3-aryl-4,5-dimethylthiazolium chloride.
Uses3-Chloro-2-butanone was used to study various carbonylic compounds as substrates for 4-hydroxyacetophenone monooxygenase from Pseudomonas fluorescens ACB.
Synthesis Reference(s)Journal of the American Chemical Society, 77, p. 5274, 1955 DOI: 10.1021/ja01625a016
General Description3-Chloro-2-butanone reacts with 1,4-dianion of acetophenone N-ethoxycarbonylhydrazone to yield pyrazoline derivatives.
3-Chloro-2-butanone Preparation Products And Raw materials
Preparation Products2,2'-BICINCHONINIC ACID-->Trimethyl thiazole

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