(-)-SPARTEINE

CAS No.：90-39-1

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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(-)-SPARTEINE Basic information

Product Name:	(-)-SPARTEINE
Synonyms:	Spartine;MINUS-SPARTEINE FREE BASE;6h-dipyrido(1,2-a:1’,2’-e)(1,5)diazocine,dodecahydro-14-methano-2h;7,14-Methano-2H,6H-dipyrido(1,2-a:1',2'-e)(1,5)diazocine, dodecahydro-;7,14-Methano-2H,6H-dipyrido[1,2-a:1',2'-e][1,5]diazocine, dodecahydro-, [7S-(7alpha,7aalpha,14alpha,14abeta)]-;Dodecahydro [7S-(7alpha,7aalpha,14alpha,14abeta)]-7,14-methano-2H,6H-dipyrido[1,2-a:1',2'-e][1,5]diazocine;Lupinidin;Spartein
CAS:	90-39-1
MF:	C15H26N2
MW:	234.38
EINECS:	201-988-8
Product Categories:	Alkaloids;Alkaloids (Others);Biochemistry
Mol File:	90-39-1.mol

(-)-SPARTEINE Chemical Properties

Melting point	30.5°C
Boiling point	137-138 °C1 mm Hg(lit.)
alpha	D21 -16.4° (c = 10 in abs alc)
density	1.02 g/mL at 25 °C(lit.)
refractive index	n20/D 1.528(lit.)
Fp	>230 °F
storage temp.	2-8°C
solubility	Chloroform (Slightly), Ethanol (Slightly)
form	liquid
pka	2.24, 9.46(at 20℃)
color	Light Yellow to Yellow
optical activity	[α]/D -17.5±1.5°, c = 1 in ethanol
Water Solubility	3.04g/L(25 ºC)
Merck	14,8737
BRN	82447

Safety Information

Hazard Codes	Xn
Risk Statements	20/21/22
Safety Statements	36
RIDADR	3140
WGK Germany	3
RTECS	WG5950000
HazardClass	6.1(b)
PackingGroup	III
HS Code	2933399990

MSDS Information

Provider	Language
SigmaAldrich	English
ALFA	English

(-)-SPARTEINE Usage And Synthesis

Chemical Properties	Viscous oily liquid; boils around 180°C(356°F); density 1.02 at 20°C (68°F); stronglybasic, a 0.01 M soln. has pH 11.6; slightlysoluble in water (0.3 g/100 mL), dissolvesreadily in alcohol, ether, or chloroform.
Uses	Sparteine occurs in yellow and black lupinbeans (Lupinus luteus L. and L. niger). Italso occurs in other Lupinus species aswell as in Cytisus and Spartium species.Therapeutically, it is used as an oxytocicagent.
Health Hazard	Toxic actions of sparteine are similar to thoseof coniine but are much less toxic than thoseof coniine. The toxic symptoms in mice weretremor, muscle contraction, and respiratorydistress. An intraperitoneal dose lethal toguinea pigs is 23 mg/kg.LD50 value, oral (mice): 220 mg/kg.

(-)-SPARTEINE Preparation Products And Raw materials

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