1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone

CAS No.：7226-23-5

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

View the full Disclaimer

Other grades of this product :

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone Basic information

Product Name:	1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone
Synonyms:	1,3-dimethyl-perhydro-2-pyrimidinone;1,3-dimethyl-tetrahydro-pyrimidin-2-one;n,n’-dimethyltrimethyleneurea;tetrahydro-1,3-dimethyl-2(1h)pyrimidine;tetrahydro-1,3-dimethyl-2(1h)-pyrimidinon;1,3-Dimethyl-2-oxohexahydropyrimidine;1,3-Dimethyltetrahydropyrimidin-2(1H)-one;DMPUN,N'-DiMethylpropyleneurea
CAS:	7226-23-5
MF:	C6H12N2O
MW:	128.17
EINECS:	230-625-6
Product Categories:	Aliskiren;bc0001
Mol File:	7226-23-5.mol

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone Chemical Properties

Melting point	-20 °C
Boiling point	146 °C44 mm Hg(lit.)
density	1.06 g/mL at 25 °C(lit.)
vapor pressure	0.5 hPa (57 °C)
refractive index	n20/D 1.488(lit.)
Fp	121 °C
storage temp.	Store below +30°C.
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
form	Liquid
pka	-0.65±0.20(Predicted)
color	Clear colorless to slightly yellow
PH	11 (100g/l, H2O, 20℃)
explosive limit	1.6-9.3%(V)
Water Solubility	soluble
Sensitive	Hygroscopic
BRN	110562
Stability:	Hygroscopic
InChIKey	GUVUOGQBMYCBQP-UHFFFAOYSA-N
LogP	0.05 at 25℃
CAS DataBase Reference	7226-23-5(CAS DataBase Reference)
EPA Substance Registry System	2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- (7226-23-5)

Safety Information

Hazard Codes	Xn
Risk Statements	22-36-43-62-41
Safety Statements	23-26-36/37/39-45
WGK Germany	2
RTECS	UW7582500
F	3-10
Autoignition Temperature	255 °C
TSCA	Yes
HS Code	29335995
Toxicity	LD50 orally in Rabbit: 1770 mg/kg

MSDS Information

Provider	Language
DMPU	English
ACROS	English
SigmaAldrich	English
ALFA	English

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone Usage And Synthesis

Chemical Properties	1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone is clear colorless to slightly yellowish liquid
Uses	1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone is a versatile organic solvent in and less toxic than HMPA. It is mainly applied in the synthesis of pharmaceuticals and agrochemicals. DMPU is also used in the electronics industry.
Uses	1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone is a versatile solvent used in the N-alkylation of chiral and O-alkylation of aldoses. It is involved in the preparation of poly(aryl ethers). It is a cyclic urea and used as a polar aprotic organic solvent. Further, it reacts with trifluoro-methanesulfonic acid anhydride to prepare 2,2'-oxy-bis(1,3-dimethyl-tetrahydropyrimidinium) bis(trifluoromethanesulfonate).
Uses	Versatile solvent employed in N-alkylation of chiral, primary amines, O-alkylation of aldoses, and in the synthesis of poly(aryl ethers).
Flammability and Explosibility	Nonflammable

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone Preparation Products And Raw materials

Raw materials	Dichloromethane-->Potassium carbonate-->1,4-Dioxane-->Dimethyl sulfate-->Benzyltriethylammonium chloride-->p-Toluenesulfonic acid monohydrate-->Propyleneurea
Preparation Products	2-MORPHOLINONICOTINALDEHYDE-->2-Chloro-3-pyridinecarboxaldehyde

Welcome！

Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.

NO. 18 ,Wujiang Road, Wulidian Street, Jiangbei District, Chongqing
+86-23-6139-8061 +86-13650506873
danny@chemdad.com sales@chemdad.com
www.chemdad.com
WhatsApp +86-13650506873