METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE

CAS No.：39977-44-1

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

View the full Disclaimer

Other grades of this product :

METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE Basic information

Product Name:	METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE
Synonyms:	METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE;METHYL-6-HYDROXYMETHYL-2-PYRIDINE-CARBOXYLATE;Methyl 6-(hydroxymethyl)picolinate;6-Hydroxymethyl-pyridine-2-carboxylic acid methyl ester;methyl 6-(hydroxymethyl)pyridine-2-carboxylate;Methyl 6-(hydroxymethyl);Methyl-6-(hydroxymethyl)pyridine-2-carboxylate≥ 97% (GC);Methyl-6-hydroxymethyl-2-carboxylate
CAS:	39977-44-1
MF:	C8H9NO3
MW:	167.16
EINECS:	809-354-8
Product Categories:
Mol File:	39977-44-1.mol

METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE Chemical Properties

Melting point	178 °C
Boiling point	327.3±32.0 °C(Predicted)
density	1.244
storage temp.	Inert atmosphere,Room Temperature
form	Solid
pka	13.03±0.10(Predicted)
color	White

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26
HS Code	2933399990

MSDS Information

METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE Usage And Synthesis

Chemical Properties	White or off-white solid
Uses	Methyl 6-(Hydroxymethyl)-2-pyridinecarboxylate is a chemical compound used in the synthesis of Losartan (L470500) derivatives as AT1 antagonists in the preparation of antihypertensive agents. Also used to prepare telomerase inhibitors for in vivo inhibitory activity.
Synthesis	Into a 100-mL round-bottom flask, was placed a solution of 2,6-dimethyl pyridine-2,6- dicarboxylate (950 mg, 4.87 mmol, 1.00 equiv) in a solvent mixture of methanol (33.2 mL) and dichloromethane (14.2 mL). NaB (185 mg, 5.02 mmol, 1.00 equiv) was added to the reaction mixture in several batches at 0°C. The resulting solution was stirred overnight at room temperature, and then it was quenched by the addition of 50 mL of NC1 (aq.). The resulting solution was extracted with 2x50 mL of dichloromethane and the combined organic layers were dried over anhydrous sodium sulfate and concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1 : 1-2: 1) as eluent to yield 750 mg (92%) of methyl 6-(hydroxymethyl)pyridine-2-carboxylate as a white solid.

METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE Preparation Products And Raw materials

Preparation Products

2-(6-(HYDROXYMETHYL)PYRIDIN-2-YL)PROPAN-2-OL

Welcome！

Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.

NO. 18 ,Wujiang Road, Wulidian Street, Jiangbei District, Chongqing
+86-23-6139-8061 +86-13650506873
danny@chemdad.com sales@chemdad.com
www.chemdad.com
WhatsApp +86-13650506873