2,6-Difluorophenylboronic acid

2,6-Difluorophenylboronic acid
  • CAS No.:162101-25-9
Other grades of this product :
2,6-Difluorophenylboronic acid Basic information
Product Name:2,6-Difluorophenylboronic acid
Synonyms:BORONICACID, B-(2,6-DIFLUOROPHENYL)-;2,6-Difluorophenylboronic acid 98%;RARECHEM AH PB 0108;CHEMBRDG-BB 3200972;AKOS BRN-0261;AKOS BRN-0146;2,6-DIMETHOXYBENZENEBORONIC ACID;2,6-DIFLUORO PHENYLBORIC ACID
CAS:162101-25-9
MF:C6H5BF2O2
MW:157.91
EINECS:627-874-1
Product Categories:Organometallic Reagents;Boronate Ester;Aryl Boronic Acids;Boronic Acids and Derivatives;Potassium Trifluoroborate;Pyridines;Substituted Boronic Acids;Fluorobenzene;Boronic Acid;Aryl;Halogenated;Organoborons;Chemical Synthesis;Disubstituted Aryl Boronic Acids;HALIDE;blocks;BoronicAcids;FluoroCompounds;B (Classes of Boron Compounds);Boronic Acids;Boronic Acids;Boronic Acids and Derivatives
Mol File:162101-25-9.mol
2,6-Difluorophenylboronic acid Chemical Properties
Melting point 147-149 °C (lit.)
Boiling point 260.1±50.0 °C(Predicted)
density 1.35±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Soluble in methanol.
form solid
pka8.12±0.58(Predicted)
color White to Almost white
BRN 8545931
InChIKeyDBZAICSEFBVFHL-UHFFFAOYSA-N
CAS DataBase Reference162101-25-9(CAS DataBase Reference)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-22
Safety Statements 26-36-37/39
WGK Germany 3
HazardClass IRRITANT
HS Code 29163990
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
2,6-Difluorophenylboronic acid Usage And Synthesis
Chemical PropertiesWhite to off-white crystalline powder
Usessuzuki reaction
Uses2,6-Difluorophenylboronic acid can be used:
  • As a substrate in the model reaction of Suzuki–Miyaura coupling with?4-chloro-3-methylanisole.
  • To prepare 4-bromo-2,3′,5′,6-tetrafluorobiphenyl, a key intermediate for the synthesis of 2,6-difluorinated oligophenyls applicable in organic semiconductors.
  • To prepare ethyl 4-(2,6-difluorophenyl)nicotinate, a key intermediate for the synthesis of 4-phenyl pyridine based potent TGR5 agonists.
UsesIntermediates of Liquid Crystals
2,6-Difluorophenylboronic acid Preparation Products And Raw materials
Raw materialsDiethyl ether-->n-Butyllithium-->Triisopropyl borate-->1-Bromo-2,6-difluorobenzene-->Water-->Trimethyl borate-->1,3-Difluorobenzene
Preparation Products2,6-Difluorophenol

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