Other grades of this product :
| Nefazodone Basic information |
| Product Name: | Nefazodone | | Synonyms: | 3h-1,2,4-triazol-3-one,2,4-dihydro-2-3-(4-(3-chlorophenyl)-1-piperazinyl)propy;l)-5-ethyl-4-(2-phenoxyethyl)-;BMY-13754;SERZONE;MJ-13754-1;NEFAZODONE;2-[3-[4-(3-CHLOROPHENYL)-1-PIPERAZINYL]PROPYL]-5-ETHYL-2,4-DIHYDRO-4-(2-PHENOXYETHYL)-3H-1,2,4-TRIAZOL-3-ONE HYDROCHLORIDE;Nefazodone base | | CAS: | 83366-66-9 | | MF: | C25H32ClN5O2 | | MW: | 470.01 | | EINECS: | | Product Categories: | API;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 83366-66-9.mol |
| Nefazodone Chemical Properties |
| Melting point | 180-182°C | | Boiling point | 599.6±60.0 °C(Predicted) | | density | 1.23±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: ~11 mg/mL at 60 °C | | form | solid | | pka | pKa 6.5 (Uncertain) | | color | white | | CAS DataBase Reference | 83366-66-9(CAS DataBase Reference) | | NIST Chemistry Reference | Nefazodone(83366-66-9) |
| Nefazodone Usage And Synthesis |
| Chemical Properties | Crystalline Solid | | Originator | Dutonin,Bristol-Myers Squibb,USA | | Uses | A selective serotonin 5-HT2 receptor antagonist. An antidepressant | | Brand name | Serzone (Bristol-Myers Squibb). | | Therapeutic Function | Antidepressant | | Biological Functions | Although nefazodone (Serzone) is structurally related
to trazodone, it is less sedating. It does not block α1-
adrenoreceptors, and its use is not associated with priapism.
Nefazodone inhibits the neuronal reuptake of
serotonin and blocks 5HT2A receptors. Its short half-life
requires dosing twice a day. Nefazodone is
not associated with weight gain or sexual dysfunction. It
inhibits the cytochrome P450 3A4 isoenzyme that is responsible
for 50% of known oxidative metabolism, and
therefore, nefazodone can elevate levels of drugs dependent
on this pathway for metabolism. |
| Nefazodone Preparation Products And Raw materials |
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